BACKGROUND Chromosomal abnormalities are an important cause of spontaneous abortion and recurrent miscarriage (RM). Therefore, we have analysed the incidence of chromosomal abnormalities and embryo development in patients with RM. METHODS Preimplantation genetic diagnosis (PGD) was performed on 71 couples with RM and 28 couples undergoing PGD for sex-linked diseases (control group). Chromosom...

Spontaneous pregnancy loss is a surprisingly common occurrence, with approximately 15% of all clinically recognized pregnancies resulting in pregnancy failure. Recurrent pregnancy loss (RPL) has been inconsistently defined. When defined as 3 consecutive pregnancy losses prior to 20 weeks from the last menstrual period, it affects approximately 1% to 2% of women. This review highlights the curre...

BACKGROUND Recurrent pregnancy loss (RPL) is a common health problem. The polymorphisms G20210A of prothrombin gene (FII G 20210A), and G 1691A of factor V gene (Factor V Leiden, FVL) are the most extensively studied thrombophilic mutations in association to recurrent miscarriage. OBJECTIVES To determine the frequency of FII G20210A and FVL polymorphisms as well as protein C and protein S def...

Recurrent pregnancy loss (RPL) is a multifactorial condition. Approximately half of patients with RPL will have no explanation for their miscarriages. De novo chromosome abnormalities are common in sporadic and recurrent pregnancy loss. Testing for embryonic abnormalities can provide an explanation for the miscarriage in many cases and prognostic information. Regardless of the cause of RPL, pat...

Recurrent pregnancy loss (RPL) also referred to as recurrent miscarriage or recurrent spontaneous abortion has been a cause for bad obstetric history along with still births, intrauterine fetal deaths and intrauterine growth retardation (IUGR). According to the Practice Committee of the American Society for Reproductive Medicine, for epidemiological studies, three or more pregnancy losses are c...

Recurrent pregnancy loss (RPL) also referred to as recurrent miscarriage or recurrent spontaneous abortion has been a cause for bad obstetric history along with still births, intrauterine fetal deaths and intrauterine growth retardation (IUGR). According to the Practice Committee of the American Society for Reproductive Medicine, for epidemiological studies, three or more pregnancy losses are c...

Recent evidences associate thrombophilia with adverse pregnancy outcome. Numerous studies confirm Factor V Leiden (FVL) and Prothrombin G20210A (PT G20210A) mutations as important thrombophilia risk factors in Caucasians. However, these mutations are rare in Asians and thrombophilia investigations are therefore considered irrelevant in these patients. Hence, the status of thrombophilia-induced ...

Loss of vision after severe and recurrent haemorrhage, an occasional but serious complication, is an established clinical entity recognized from the writings of the earliest medical authorities. Formerly thought only to follow recurrent upper gastrointestinal (Goerlitz, 1920; Bamford and Barber, 1940; Black, '945; Avery Jones, 1947; Locket, I949; Gavey, I963), uterine (Pines, 1931), or therapeu...

Preimplantation genetic diagnosis (PGD) testing is the practice of obtaining a cellular biopsy sample from a developing human oocyte or embryo, acquired via a cycle of in vitro fertilization (IVF); evaluating the genetic composition of this sample; and using this information to determine which embryos will be optimal for subsequent uterine transfer. PGD has become an increasingly useful adjunct...