INTRODUCTION We report a successful case of immune tolerance to factor VIII (FVIII) inhibitor after a major operation. An attempt was made to induce immune tolerance with inhibitor in a haemophilia A patient, who was required to undergo an above-knee amputation. We opted to give high-dose FVIII infusion with no immunosuppression. OUTCOME The highest preoperative FVIII inhibitor level was 5 BU...

Abstract Background Most epidemiological studies into venous thromboembolism (VTE) are based on the white Caucasian population and unrepresentative of VTE outcomes in non-white ethnicities. Purpose Our registry aims to get an insight patients as applicable a developed world with multi-ethnic background. This will guide clinicians make appropriate decisions regards management prognosis. Methods ...

INTRODUCTION Synovial hemangioma is a rare condition with <200 published case reports in world literature and is frequently misdiagnosed, leading to diagnostic delay of many years. This delay is even more significant if the patient comes from a rural background with a dearth of medical facilities in the area. This case had a lag of nearly 20 years from the time of onset of symptoms and the requ...

Most problems encountered in complex revision total knee arthroplasty can be managed with the wide range of implant systems currently available. Modular metaphyseal sleeves, metallic augments and cones provide stability even with significant bone loss. Hinged designs substitute for significant ligamentous deficiencies. Catastrophic failure that precludes successful reconstruction can ...

Patients and methods We herein report a 23-year-old Japanese male who suffered from recurrent arthritis in his knee and ankle joints, pyoderma gangrenosum, and acne. Recently, he had experienced melena and multiple colonic ulcers had been detected by colonfiberscopy. His ulcerations resembled ulcers associated with Crohn’s disease. A histological examination was then performed for the synovium ...

Pigmented villonodular synovitis (PVNS) is a rare, benign, but potentially locally aggressive and recurrent condition characterized by synovial proliferation and hemosiderin deposition inside the joints, tendon sheaths, and bursae. It usually affects the large joints such as hip, knee, and ankle. We report a case of PVNS of the knee joint in a young female which was treated by subtotal synovect...

Hemarthrosis, the hallmark of severe hemophilia, is the major cause of serious bleeding events, disability and reduced quality of life in patients with factor VIII or factor IX deficiency. Joint bleeding is one of the greatest challenges confronting individuals treating hemophilia, and its economic impact is enormous. This article reviews the current management of hemophilic joint bleeding and ...

Bleeding into the joints is common in patients with hemophilia. After total knee or elbow replacement, profuse intraarticular bleeding unresponsive to high-dose clotting factor replacement sometimes occurs. In some patients who have severely damaged elbow or knee joints the same profuse bleeding pattern can be seen. To control bleeding in these patients, selective catheterization with a microca...

INTRODUCTION Haemophilic arthropathy following recurrent joint bleedings is one of the major disease-related complications in people with haemophilia (PWH), leading to mostly chronic joint pain. Since many antinociceptive principles interfere with the clotting system, PWH are restricted in treatment options, thereby defining a medical need for novel therapeutic principles. However, we lack the ...

A 52-year-old man with no significant medical history presented to the emergency department (ED) after a mechanical fall onto his nondominant left hand. Physical examination was suggestive of a glenohumeral dislocation, and radiographs confirmed a subcoracoid anterior glenohumeral dislocation (Figure 1). The patient was neurovascularly intact, but complained of severe pain and refused initial a...