BACKGROUND The true relationship between methylenetetrahydrofolate reductase C677T homozygosity and risk of recurrent spontaneous abortion is unknown, and it is unclear if women with these mutations should be anticoagulated during pregnancy. OBJECTIVES We report a series of 8 patients with this issue and review the current literature. METHODS 8 patients (3 of whom were actively pregnant) we...

Objective: To predict pregnancy outcome by studying the relation between serum βHCG, progesterone and CA125 occurrence of miscarriage in first trimester, cases with history recurrent loss. Methods: Serum levels fifty pregnant women loss were compared to 50 no abortion, another group (No=50) who failed complete 1st trimester during study. Results: B-hCG showed a sensitivity 100%, specificity 50%...

OBJECTIVE To explore the association of non-organ-specific autoimmune responses against three distinct Ro antigen-related reactivities (Ro52, Ro60, p57) with a history of pregnancy loss in women with autoimmune disorders. Materials and methods. Seventy unselected anti-Ro/SSA-positive women were studied in a retrospective cohort study. Forty anti-Ro/SSA-positive women were age matched to an equa...

abstract background a vast variety of factors may cause recurrent pregnancy loss. blood group incompatibility of parents could cause abortion. the examination of couples or twins, blood groups showed that the blood group incompatibility can affect adversely the outcome of pregnancy. couples with blood group incompatibility are more involved in spontaneous miscarriage. antigenes in two different...

Thromb Haemost 2006; 95: 900–1 Hyperhomocysteinaemia is a risk factor for thrombosis and recurrent pregnancy loss (1–2). Similar mechanisms appear to mediate thrombosis and pregnancy loss associated with hyperhomocysteinaemia and with antiphospholipid antibodies (3). We report the case of a female patient with an unusual association of hyperhomocysteinemia, normocalcemic hyperparathyroidism, gr...

Pregnancy is hypercoagulable state. The field of thrombophilia; the tendency to thrombosis, has been developed rapidly and has been linked to many aspects of pregnancy. It is recently that severe pregnancy complications such as severe preeclampsia, intrauterine growth retardation, abruptio placentae and stillbirth has been shown to be associated with thrombophilia. Recurrent miscarriage has als...

Background: The aim of the conservative treatment is the regression of the hyperplastic to normal endometrium. Conservative treatment of endometrial hyperplasia is based on the administration of agents with either antioestrogenic action or direct anti-proliferative effect on the endometrium. Progestagens have been used widely in the treatment of endometrial hyperplasias. Materials and Methods: ...

objective: several studies have shown the improving effect of heparin on the outcomes of art. moreover, it has been reported that adding heparin in non-thrombophilia patients with rif is useful.the aim of this study was to evaluate the beneficial effects of heparin on art outcomes in women with history of recurrent implantation failure (rif) and without history of congenital or acquired thrombo...

Background and Aims: Recurrent pregnancy loss (RPL) is one of the important complications of pregnancy. Only 50% of cases have a known cause of RPL. One of the causes of RPL is Waddlia Chondrophila (W. Chondrophila), but no information is available regarding its in Iran. This study aimed to develop a Taqman Real-Time polymerase chain reaction assay to detect recA Gene of W. Chondrophilain biolo...

The prognosis of couples with recurrent miscarriage is controversial despite efforts made during this century to learn about the physiopathology and treatment of this troublesome condition. Here we present our experiences of employing oocyte donation in eight couples in whom the woman was a low responder to gonadotrophin stimulation and had a previous history of recurrent abortion with negative...