Pancreatic beta cell (β) dysfunction is an outcome of malnutrition. We assessed the role of the amplifying pathway (AMP PATH) in β cells in malnourished obese mice. C57Bl-6 mice were fed a control (C) or a low-protein diet (R). The groups were then fed a high-fat diet (CH and RH). AMP PATH contribution to insulin secretion was assessed upon incubating islets with diazoxide and KCl. CH and RH di...

Development of aesthetic restorations requires a careful, thorough, and concise team approach. The correct design of the gingival margin will significantly affect the overall appearance of the restorations, and the development of scalloped interdental papillae is equally paramount to restorative success. Tooth morphology can only be reestablished in a natural way when the soft tissue is compati...

Holding phone conversations while driving is dangerous not only because it occupies the hands, but also because it requires attention. Where driver and passenger can adapt their conversational behavior to the demands of the situation, and e.g. interrupt themselves when more attention is needed, an interlocutor on the phone cannot adjust as easily. We present a dialogue assistant which acts as ‘...

Mice lacking the proneural transcription factor Math1 (Atoh1) lack multiple neurons of the proprioceptive and arousal systems and die shortly after birth from an apparent inability to initiate respiration. We sought to determine whether Math1 was necessary for the development of hindbrain nuclei involved in respiratory rhythm generation, such as the parafacial respiratory group/retrotrapezoid n...

Sepsis in the immunosuppressed patient is associated with very high mortality and morbidity. Treatment of sepsis in immunocompromised patients is especially challenging due to an unbalanced systemic inflammatory reaction with subsequent development of profound vasoplegia. Methylene blue (MB) has been successfully used for the treatment of refractory hypotension, but its use has not previously b...

Introduction: Acinetobacter baumannii has been considered a prevalent pathogen in hospitals, raising concern in the medical community due to its broad spectrum of antimicrobial resistance. Since it is a subject that arouses much interest, it has been increasingly studied. Due to the emergence of multidrug-resistant (MDR) Gram-negative bacteria, the use of polymyxins was reestablished. The polym...

Endothelial cells were prepared from bovine brain microvessels and grown in tissue culture. They contained factor VIIIivon Willebrand antigen, the most specific marker available for determination of the endothelial origin of cells in culture. The cultured cells formed complex tight junctions and contained few pinocytotic vessels. These properties are responsible for formation of the blood-brain...

A reexamination of satellite-derived sea surface temperature imagery reveals many examples of Brazil Current rings, both warm and cold, in dipole configurations. The dynamical significance of the dipole model is established by considering the interaction of a cold (cyclonic) eddy with a warm (anticyclonic) ring. The ring is shown to exist as a dipole for about 60 days, or two rotation periods b...

BACKGROUND Cerebral dural sinus thrombosis is a rare clinical entity. Symptoms may be vague, and left untreated thrombus progression may be fatal because of venous congestion and infarction. METHODS We report a case of post-traumatic dural sinus thrombosis treated with selective transfemoral, transvenous catheterization and infusion of urokinase. RESULTS Urokinase infusion into the dural ve...

The patient was a healthy adolescent who suffered blunt abdominal trauma while skiing (direct impact of the abdomen against a post). He was brought to the emergency department of our hospital by ambulance. On admission, the patient was hemodynamically stable (blood pressure: 110/70 mmHg, HR: 80) with hemoglobin 12 g/ dl. He presented multiple abdominal erosions with signs of Digestive continuit...