background: the study was aimed to explore the association between arterial oxygen saturation (spo2) and spirometer parameters of disease severity in copd patients with a view to identify whether the pulse oximetry can be used as an alternative to arterial values in the clinical management of copd patients in a routine practice. materials and methods: thirty-one patients with copd were included...

Nicolae Iagaru e-mail: [email protected] Abstract. TB arthritis is a rare, insidious chronic mono-arthritis resulting in extremely serious destruction of joints and bones. Usually, the possibility of TB arthritis is suggested by family infectious or environmental contact with TB and a positive Test at PPD. The Objectives. Are to discuss about a forgotten etiology of monoarthritis in pedi...

Clozapine is a gold standard medication and drug of choice in refractory schizophrenia. Among many of its fatal side effects, delirium is less reported and inconsistently recognized by clinicians. We here present a case of delirium which emerged during retreatment with clozapine in a patient of paranoid schizophrenia. A patient diagnosed with paranoid schizophrenia, was restarted on clozapine a...

a chronic course, and are infinitely more refractory to treatment are, as a rule, dismissed with the briefest reference. It is, of course, possible that in the localities where it has been chiefly studied, Ceylon, Haiti, Cochin China, the Gold Coast and Central Africa, the secondary eruptions are found in greater profusion than in the relatively temperate climate of Assam.* Be the explanation w...

Epithelial ovarian cancer (EOC) is the sixth most common malignancy in women. Ovarian tumors consist of several clinical and pathological entities that share an anatomic site. The gold standard treatment, both in front-line and in adjuvant setting, is represented by carboplatin/paclitaxel combination. Conversely, the second-line treatment is not well defined. The response to platinum is the maj...

Laparoscopic cholecystectomy is the gold standard method for treating gallstone related disease. Despite its widespread and well established application, clear consensus is not arrived at regarding the comparative risks and benefits of acute versus interval cholecystectomy. The complications of this technique are well known, with respect to both the operative intervention and the technique used...

Gastrointestinal stromal tumours (GISTs) are rare mesenchymal lesions accounting for only 0.2% of all gastrointestinal neoplasms. These tumors arise from the interstitial cells of Cajal, with mutations described in proto-oncogenes such as KIT, PDGFRA, DOG-1, and SDH. The majority of these lesions are asymptomatic, thus the true incidence remains unknown. While patients typically undergo initial...

The failure rate for phase III trials in oncology is high; quantitative predictive approaches are needed. We developed a model-based meta-analysis (MBMA) framework to predict progression-free survival (PFS) from overall response rates (ORR) in relapsed/refractory multiple myeloma (RRMM), using data from seven phase III trials. A Bayesian analysis was used to predict the probability of technical...

Heart transplantation is currently the definitive gold standard surgical approach in the treatment of refractory heart failure. However, the shortage of donors limits the achievement of a greater number of heart transplants, in which the use of mechanical circulatory support devices is increasing. With well-established indications and contraindications, as well as diagnosis and treatment of rej...