BACKGROUND AND OBJECTIVES Relapsed non-Hodgkin's lymphoma (NHL) is preferably treated with high-dose therapy and stem cell support. However, not all patients qualify for intensive chemotherapy. We evaluated the efficacy and toxicity of a new salvage chemotherapy regimen designed for patients with relapsed or refractory NHL who are not appropriate candidates for high-dose therapy (HDT). DESIGN...

Non-Hodgkin lymphoma (NHL) causes many deaths worldwide with increasing incidence. Non-Hodgkin's lymphoma (NHL) may involve the gynecologic tract, and the ovary to be one of the commoner anatomic sites as reported. Ovarian involvement by NHL is usually secondary, occurring as a part of systemic disease. The diagnosis is often made incidentally while investigating for gynecological symptoms. We ...

BACKGROUND There is a dearth of published literature on the frequency and distribution of pediatric and adolescent non-Hodgkin lymphoma (NHL) in India according to the 2001 WHO classification. The aim of this study was to record the distribution of the different subtypes, analyze the major subtypes, and compare it with the published data from other countries. A review of pediatric NHL statistic...

Background: Epstein-Barr virus (EBV) infection is highly associated with specific subtypes of malignant lymphoma such as types of aggressive non-Hodgkin lymphoma (NHL). We aimed to evaluate the prevalence of EBV in NHL and its association with clinical parameters. Patients and Methods: twenty cases entered to our study. After re-blocking of previous paraffin embedded specimens, new slides were ...

The distribution of non-Hodgkin lymphoma (NHL) subtypes differs around the world but a systematic study of Latin America has not been done. Therefore, we evaluated the relative frequencies of NHL subtypes in Central and South America (CSA). Five expert hematopathologists classified consecutive cases of NHL from 5 CSA countries using the WHO classification and compared them to 400 cases from Nor...

background epstein barr virus (ebv) is one of the most common viral infections in human population. ebv has a significant role in pathogenesis of hodgkin's lymphoma, burkitt's lymphoma and nasopharyngeal carcinoma. the role of ebv in non-hodgkin’s lymphoma, diffuse large b cell (nhl - dlbl) in the head and neck is controversial. objectives the purpose of this study is to find out the ...

Tumor immunotherapy based on the use of chimeric antigen receptor modified T cells (CAR T cells) is a promising approach for the treatment of refractory hematological malignancies. However, a robust response mediated by CAR T cells is observed only in a minority of patients and the expansion and persistence of CAR T cells in vivo is mostly unpredictable.Lenalidomide (LEN) is an immunomodulatory...

Background: Efforts were made in order to identify the etiologic factors in pediatric cancers. Several studies have suggested a probable etiologic association between lymphoma and Epstein-Barr virus (EBV); therefore, the aim of this study was to investigate the association of EBV in childhood lymphoma. Materials and method: Paraffin block of 63 pediatric patients with lymphoma was studied for d...

I have studied and worked with non-Hodgkin lymphoma (NHL) for at least 16 years in the Hospital das Clínicas and Instituto do Câncer do Estado de São Paulo of the Faculdade de Medicina da Universidade de São Paulo (FMUSP). Last year we attended 300 new patients with NHL and 49.5% (almost 150 patients) had diffuse large B-cell lymphoma (DLBCL). This is in agreement with the literature that descr...

BACKGROUND Although renal involvement is often present in non-Hodgkin's lymphoma (NHL), primary renal NHL is a rare diagnosis. CASE PRESENTATION We present a case report of a 72-year-old asymptomatic male who underwent a robot-assisted laparoscopic radical nephroureterectomy on an atrophic left kidney with evidence of an infiltrating mass. Pathology report demonstrated a grade 1 follicular ly...