The objective of this study was to develop once-daily metformin hydrochloride sustained-release tablets (MHSRT) and evaluate their in vitro release behavior. MHSRT were prepared by the film coating method. The in vitro drug release rate of MHSRT and the commercial tablets Fortamet made in the United States of America in water was fitted with zero order kinetic equation, and Ritger-Peppas kineti...

in the first impounding of rockfill dams, additional settlements occur in upstream side in saturated rockfills due to collapse phenomenon even high rainy seasons can cause additional deformation in the dumped rockfills. unfortunately these displacements are not taken into account in the conventional numerical models which are currently used to predict embankment dam behavior during impounding. ...

Feeding behavior of adult rainbow trout (Oncorhynchus mykiss) is released by visual and/or chemical stimuli. Detection of either a conditioned visual or a conditioned chemical stimulus creates an excitatory feeding state within the central nervous system which turns on feeding behavior composed of swimming, turning and biting/snapping actions. Particular amino acids that are highly effective ph...

The adjustment of captive-reared and developmentally deprived ringtailed lemurs (Lemur catta) to supported release on St. Catherine's Island, Georgia, was studied over 7 years to examine if these animals developed behavior comparable to wild populations. Initial changes after release included decreased obesity and increased agility as well as foraging for appropriate novel plants. Ranging, dail...

The pheromone nereithione (cysteine-glutathione disulfide), which is released by swimming females of the polychaete Nereis succinea to activate spawning behavior of N. succinea males, has recently been identified and synthesized. Nereithione activates sperm release at less than 10(-6) M, one to two orders of magnitude less than oxidized glutathione or any other glutathione derivative tested. Th...

The attenuation of high pressure shock waves has been investigated. High purity copper, 6061-T6 aluminum, 6A1-4V and a phase titanium, an uranium alloy and two alloys of beryllium were examined experimentally at pressures as high as 3 megabars. Low pressure experiments were instrumented with a velocity laser interferometer. Intermediate pressures (to several hundred kilobars) were instrumented ...

Photo-crosslinked networks were prepared from fumaric acid monoethyl ester-functionalized poly(D,L-lactic acid) oligomers and N-vinyl-2-pyrrolidone. Two model proteins, lysozyme and albumin, were incorporated into the network films as solid particles and their release behavior was studied. By varying the NVP content and macromer molecular weight the degradation behavior and protein release prof...

Objective(s): Nanoparticles (NPs) are known for their specific accumulation in the inflamed tissues of the colon and thus allow a selective delivery to the site of inflammation with minimum adverse effects. The main objective of this work is to attain mesalamine loaded chitosan nanoparticles as a carrier for oral delivery. Methods: In this study, me...

Sodium salicylate containing microemulsions have been formulated, based on the previous phase diagram studies, using a pharmaceutically acceptable surfactant and oil. The effects of formulation variables on the release profile of the drug from microemulsion through intact rat skin were also determined experimentally. In this investigation, two commercially available lecithins (namely Epikuron 2...

The acute wound healing process requires a quick and short-stage vascular endothelial growth factor (VEGF) supply, especially, in the early-stage of injury. To date, research has rarely met demand for controlled VEGF release. Herein, novel wheel spinning technique was introduced to fabricate alginate (Alg)/silk fibroin (SF) composite fiber loading achieving controllable In turn, it demonstrated...