BACKGROUND Type 2 diabetes is associated with macro- and microvascular complications in man. Microvascular dysfunction affects both cardiac and renal function and is now recognized as a main driver of cardiovascular mortality and morbidity. However, progression of microvascular dysfunction in experimental models is often obscured by macrovascular pathology and consequently demanding to study. T...

OBJECTIVE Inflammation is associated with both chronic kidney dysfunction and type 2 diabetes. Adiponectin, a novel circulating anti-inflammatory protein made by adipocytes, has been reported to be lower in diabetic than nondiabetic subjects. In contrast, serum levels of adiponectin are elevated in end-stage renal disease. We sought to investigate the relation between adiponectin and mild to mo...

Background: Chronic kidney disease is associated with abnormal regulation of arterial tone throughout various vascular beds. It is however unknown whether generalized vascular dysfunction precedes the development of kidney disease. We studied myogenic constriction and endothelium-mediated dilatory responses in two inbred Fawn-Hooded (FH) rat strains, one of which (FHH) spontaneously develops hy...

Uremic Cardiomyopathy thought to be the pathological cardiac hypertrophy, indicating influence of impaired renal function on myocardium. It is result pressure overload, volume and uremic state itself. LV overload occurs frequently from hypertension arteriosclerosis, occasionally aortic stenosis; as a presence an arteriovenous fistula, anemia, hypervolemia. Cardiovascular complications are major...

BACKGROUND Permanent renal dysfunction is considered as being a serious complication which may occur after major surgery and which furthermore may lead to increased morbidity and mortality. The objective of this study was to analyze the incidence of long-term postoperative renal dysfunction after primary total hip and knee joint replacements. METHODS Long-term postoperative renal dysfunction ...

Renal dysfunction is common during episodes of acute decompensated heart failure, and historical data indicate that the mean creatinine level at admission has risen in recent decades. Different mechanisms underlying this change over time have been proposed, such as demographic changes, hemodynamic and neurohumoral derangements and medical interventions. In this setting, various strategies have ...

BACKGROUND: COVID-19 has been at the forefront of public and scientific attention since initial report in December 2019. The kidney is one target organs the causative SARS-CoV-2 virus. OBJECTIVE: aim this article to discuss current understanding renal disease from a primary care perspective, with caveat that our knowledge pathogenesis, clinical course outcome still rapidly evolving. DISCUSSION:...

Renal protection against diabetes-induced pathogenic injuries by multiple exposures to low-dose radiation (LDR) was investigated to develop a novel approach to the prevention of renal disease for diabetic subjects. C57BL/6J mice were given multiple low-dose streptozotocin (STZ; 6 x 60 [corrected] mg/kg) to produce a type 1 diabetes. Two weeks after diabetes onset, some of diabetic mice and age-...

BACKGROUND Stress-induced cardiomyopathy (sCMP) is characterized by transient wall-motion abnormalities involving the left ventricular apex and mid-ventricle that are precipitated by emotional or physical stress. As the heart and kidney influence each other's function through bidirectional pathways, sCMP can induce renal dysfunction or be induced by renal dysfunction. This study reviewed the cl...

We read with interest the article “A prospective study about impact of renal dysfunction and morbidity and mortality on cardiovascular events after ischemic stroke” by Penko et al. [1]. They aimed at investigating the impact of renal dysfunction on future cardiovascular (CV) events and total mortality in patients suffering from ischemic stroke. They demonstrated that the patients with ischemic ...