OBJECTIVE Rituximab (RTX) is a B cell depleting agent used to induce and maintain remission in patients with granulomatosis with polyangiitis (GPA). As the development of hypogammaglobulinaemia in GPA patients on long-term RTX has not been addressed, the aim of this study was to investigate changes in immunoglobulin levels and risk factors for hypogammaglobulinaemia during long-term RTX mainten...

• Anti-neutrophil cytoplasmic antibody (ANCA)associated systemic vasculitis (AASV) is not a contraindication to renal transplantation. Despite the risk of disease recurrence post-transplantation, patient and graft outcomes in AASV are similar to those of renal transplant recipients with other causes of renal failure. • The optimal timing for renal transplantation in patients with AASV has not b...

BACKGROUND Corticosteroids are the basis of treatment for nephrotic syndrome due to minimal change disease (MCD), but 25% of patients have frequently relapsing nephrotic syndrome (FRNS) and 30% become steroid dependent. Prolonged use of conventional immunosuppressants causes significant toxicity. Rituximab (RTX) is now included in guidelines for childhood MCD. Evidence for use in adult MCD is l...

Approximately 1,700 cases of renal transplantation are performed annually, and various diseases may occur due to long-term internal use postoperative immunosuppressants. We experienced a case cervical cancer, which is thought be human papillomavirus (HPV)-related after living kidney transplantation, underwent laparoscopic radical hysterectomy.

RENAL transplantation was a hot topic at the 60th European Renal Association (ERA) Congress 2023, which took place both virtually and in-person in Milan, Italy, between 15th–18th June. One such session saw experts transplant medicine, surgery, ethics deliver presentations on deceased donor kidney transplantation. Co-chaired by Marta Crespo, Hospital del Mar, Barcelona, Spain, Christophe Mariat,...

Clostridium difficile toxin A is a colonic inflammatory agent that acts partially by activation of TRPV1 (transient receptor potential vanilloid type 1). Resiniferatoxin (RTX) is an excitotoxin that activates TRPV1 at low concentrations and defunctionalizes TRPV1 at high concentrations. RTX at various doses was injected intraluminally into isolated ileal segments in anesthetized rats. After 3 h...

The highly potent vanilloid receptor (VR) agonist resiniferatoxin has been radiolabeled with 125I, and the pharmacology to the cloned rodent VR, VR1, and the endogenous VR in rat spinal cord membranes has been characterized. [125I]RTX binding to human embryonic kidney 293 cells expressing VR1 was reversible and with high affinity (Kd = 4.3 nM) in an apparent monophasic manner. In rat spinal cor...

Renal vasculatures variations was normally found. Awareness of these variation was useful in many clinical fields procedures. During the routine dissection of posterior abdominal wall of approximately a 67 year old male formaldehyde cadaver. The left kidney present with arterial variation. An accessory renal artery was detected arising from the lateral aspect of the abdominal aorta at level dis...

The discovery in the late 1940s of the very potent anti-inflammatory and immunosuppressive properties of glucocorticoids (GC) has dramatically improved the prognosis of severe systemic lupus erythematosus (SLE), with survival rates increasing markedly from 50% at 3 years in 1953 to 92% at 10 years in recent series. In particular, intravenous pulse methylprednisolone (MP) therapy, introduced as ...

nuclear medicine imaging is routinely used for evaluation of perfusion and function of the transplanted kidneys. at present, the radiopharmaceutical of choice for this study in our center is tc 99m-ec. complications of the kidney graft are demonstrable in the early and delayed images. one of these complications is vesicoureteral reflux to the graft or to the native kidneys. we present a 27 year...