OBJECTIVE Long-term mental fatigue following traumatic brain injury is endorsed as one of the most distressing symptoms, interfering considerably with return to work and social life. The objective of this cross-sectional study was to estimate the prevalence of long-term mental fatigue after traumatic brain injury and to evaluate its association with employment status. METHODS All patients (ag...

head trauma is the most common form of accidental injury among children, which is a source of concern for parents and pediatricians. after head trauma, children may be loss of intellectual function. most head trauma in children is minor and not related with brain injury or long-term outcome. however, a small number of children may have a clinically important traumatic brain injury. the incidenc...

BACKGROUND We sought to determine the lifetime prevalence of traumatic brain injury and its association with current health conditions in a representative sample of homeless people in Toronto, Ontario. METHODS We surveyed 601 men and 303 women at homeless shelters and meal programs in 2004-2005 (response rate 76%). We defined traumatic brain injury as any self-reported head injury that left t...

Objective(s):Melatonin is known as an anti-inflammatory agent, and it has been proven to exert neuroprotection through inhibition of cell death (apoptosis) in several models of brain injury.Secondary injury following the primary traumatic brain injury (TBI) results in glial cells activation, especially astrocytes. In fact, astrocyte activation causes the production of pro-inflammatory cytokines...

BACKGROUND Little empiric research has investigated the interrelationship between homelessness and traumatic brain injury. The objectives of this study were to determine the rate, mechanisms and associated outcomes of traumatic brain injury among men in an urban homeless shelter. METHODS We recruited participants from an urban men's shelter in Toronto, Ontario. Researchers administered the Br...

BACKGROUND The incidence of post-traumatic stress disorder (PTSD) after traumatic brain injury is unclear. One issue involves the validity of diagnosis using self-report questionnaires. AIMS To compare PTSD'caseness' arising from questionnaire self-report and structured interview. METHOD Participants (n=34) with traumatic brain injury were recruited. Screening measures and self-report quest...

Almost a century ago, the first clinical account of the punch-drunk syndrome emerged, describing chronic neurological and neuropsychiatric sequelae occurring in former boxers. Thereafter, throughout the twentieth century, further reports added to our understanding of the neuropathological consequences of a career in boxing, leading to descriptions of a distinct neurodegenerative pathology, term...