A receptor-ligand interaction can evoke a broad range of biological activities in different cell types depending on receptor identity and cell type-specific post-receptor signaling intermediates. Here, we show that the TNF family member LIGHT, known to act as a death-triggering factor in motoneurons through LT-βR, can also promote axon outgrowth and branching in motoneurons through the same rec...

In this paper, we attempts to learn a single metric across two heterogeneous domains where source domain is fully labeled and has many samples while target domain has only a few labeled samples but abundant unlabeled samples. To the best of our knowledge, this task is seldom touched. The proposed learning model has a simple underlying motivation: all the samples in both the source and the targe...

INTRODUCTION: The purpose of this work was to reduce the time needed for whole brain resting-state functional connectivity imaging (R-fMRI) using an EPI sequence with sufficiently thin slices that signal dropout from intravoxel dephasing no longer occurs. Functional connectivity across the whole brain requires acquisition of each whole-brain dataset within a TR value that is approximately the s...

OBJECTIVE Perceived stress; emotional eating; anhedonia; depression and dietary restraint, hunger, and disinhibition have been studied as risk factors for obesity. However, the majority of studies have been cross-sectional and the directionality of these relationships remains unclear. In this longitudinal study, we assess their impact on future weight change. METHODS Psychological predictors ...

(Eden). But not a word of guidance. My case of measles was a Shetlander, aged 31, v-para, who had not had measles previously. To add to her anxiety her last confinement, two years previously, had been abnormal, an arm and the cord being prolapsed, but it ended happily. She also had felt far from well all through this pregnancy. About a fortnight before term one of her older children developed m...

A combination of anatomical, histological and physiological data from wild-type and null-mutated mice have established crucial roles for BDNF and NT3 in gustatory and somatosensory innervation of the tongue, and indeed for proper development of the papillary surface of the tongue. BDNF is expressed in taste buds, NT3 in many surrounding epithelial structures. Absence of BDNF in mice leads to se...

X have already published details of several cases of amoebic dysentery, hepatitis and liver abscess successfully treated by hypodermic injections of soluble salts of emetine (1 and 2) in which the rapidity of recovery from both very acute and very chronic attacks was 1 emavkable. Wrhat is wanted, however, to enable the merits of the new method to be estimated, is a consecutive series of cases o...

Individual differences in cognitive efficiency, particularly in relation to working memory (WM), have been associated both with personality dimensions that reflect enduring regularities in brain configuration, and with short-term neural plasticity, that reflects task-related changes in brain connectivity. To elucidate the relationship of these two divergent mechanisms, we tested the hypothesis ...

Phasic and tonic γ-aminobutyric acidA (GABAA) receptor-mediated inhibition critically regulate neuronal information processing. As these two inhibitory modalities have distinctive features in their receptor composition, subcellular localization of receptors, and the timing of receptor activation, it has been thought that they might exert distinct roles, if not completely separable, in the regul...

abstract introduction: in this study the role of pge2 as an important inflammatory mediator in indomethacine and theophylline effects on joint diameter and vascular response of chronically inflamed rat knee joint to saphenous nerve stimulation was investigated. methods: inflammation was induced by intraarticular injection of 0.2 ml freund,s complete adjuvant (fca) and 3, 7, 14, 21 days post inj...