Background The nasal epithelium represents the first barrier against entry of airborne particles into the respiratory system and therefore protects against allergens, pollutants and pathogens. We have previously used the respiratory epithelial cell line 16HBE14oto define factors which can impair the barrier function of the respiratory mucosa. However, cultures of primary epithelial cells obtain...

OBJECTIVE To establish incidence rates, clinic referrals, hospitalisations, mortality rates and baseline determinants of morbidity among infants in an Indian slum. DESIGN A community-based birth cohort with twice-weekly surveillance. SETTING Vellore, South India. SUBJECTS 452 newborns recruited over 18 months, followed through infancy. MAIN OUTCOME MEASURES Incidence rates of gastrointe...

BACKGROUND Respiratory syncytial virus (RSV) lower respiratory tract disease (LRD) is a life-threatening complication in hematopoietic cell transplant (HCT) recipients. Lymphopenia has been associated with an increased risk of progression from upper respiratory tract infection (URI) to LRD. METHODS This study retrospectively analyzed the significance of lymphocyte engraftment dynamics, lung f...

Respiratory syncytial virus (RSV) bronchiolitis is a common infection in young children and may result in hospitalization. We examined the incidence of, and risk factors associated with, hypoxemia and respiratory failure in 216 children aged < 24 months admitted consecutively for proven RSV bronchiolitis. Hypoxemia was defined as SpO2 < 90% in room air and severe RSV bronchiolitis requiring int...

BACKGROUND The aim of this study was to detect the associations between bovine herpesvirus 1 (BHV-1) status of a herd and respiratory disease (BRD) occurrence and reproductive performance in pregnant heifers and cows. The association between management-related factors and higher BRD occurrence was also estimated. METHODS Serum samples, collected from cows and youngstock from 103 dairy cattle ...

Sleep related respiratory dysfunction and vocal cord paralysis are considered to be the major factors responsible for respiratory failure in multiple system atrophy (MSA). We report a patient initially presenting with alveolar hypoventilation culminating in respiratory failure, ultimately diagnosed as MSA. No central sleep apnea or marked paralysis of the vocal cords was noted. The most likely ...

Respiratory distress syndrome occurs in a variety of clinical situations of which sepsis is one important precipitating factor. We have observed and successfully treated with high PEEP (positive end-expiratory pressure) a rare case of chromobacterial septicaemia complicated by an acute respiratory distress syndrome. We describe here the first reported case of a patient in this country surviving...

Multiple factors have been identified as elements of the respiratory disease complex in Rocky Mountain bighorn sheep (Ovis canadensis canadensis). We hypothesized that differences in health factors and Pasteurellaceae in the upper respiratory tracts could exist between populations of bighorn sheep with and without histories of pneumonic epizootics. We evaluated bighorn sheep in the Big Creek ar...

RSV infection is a leading cause of lower respiratory tract infection, especially in High-risk infants with a history of prematurity, bronchopulmonary dysplasia (BPD), congenital heart disease (CHD), neuromusculair impairment, immunodeficiency, and Down syndrome. Host related risk factors that have been identified to be associated with severe RSV related lower respiratory tract infection includ...

Pneumococcal serotypes are one of the main determinants of pneumococcal disease severity; however, data about their implication in respiratory failure are scarce. We conducted an observational study of adults hospitalised with invasive pneumococcal pneumonia to describe the host- and pathogen-related factors associated with respiratory failure. Of 1258 adults with invasive pneumococcal disease,...