A serious problem facing many organizations today is the need to use information from multiple data sources that have been developed separately. Conflicts in the structure and semantics of these disparate data sources create major obstacles to effective use. We have previously described our data mediation approach to this problem and our implementation of an RMI-based mediation service with JDB...

Multimedia streaming is difficult on the Internet, especially for video due to the large frame size and inter-frame dependencies resulted from high compression rates. This paper shows that router support for priority-based queue management could significantly improve performance of video streaming. We extend Rate-Based RED (Rb-RED) to Rate-Based RIO (Rb-RIO) which support three priority classes...

Many cell therapies currently being tested are based on mesenchymal stromal cells (MSCs). However, MSCs start to enter the senescent state upon long-term expansion. The role of retinoblastoma (RB) protein in regulating MSC properties is not well studied. Here, we show that RB levels are higher in early-passage MSCs compared with late-passage MSCs. RB knockdown induces premature senescence and r...

The scaffold protein Spinophilin (SPN) is a regulatory subunit of phosphatase1a located at 17q21.33. This region is frequently associated with microsatellite instability and LOH containing a relatively high density of known tumor suppressor genes, including BRCA1. Several linkage studies have suggested the existence of an unknown tumor suppressor gene distal to BRCA1. Spn may be this gene, but ...

Mediation does not only mean a specific procedure or protocol but the related attitude, mindset as well. This perspective gives opportunity to demonstrate the problem in a different way than previously. In the present study the participatory theory of communication (PTC) appears as a framework which makes the communication of participants of the mediation interpretable and transparent.

The effects of endogenous and synthetic glucocorticoids on fetal lung maturation are well-established, although the role of leptin in lung development before birth is unclear. This study examined mRNA and protein levels of the signalling long-form leptin receptor (Ob-Rb) in fetal ovine lungs towards term, and after experimental manipulation of glucocorticoid levels in utero by fetal cortisol in...

The retinoblastoma (RB) tumour suppressor gene is implicated in the development of several malignancies including osteosarcoma. Recent studies postulated its loss of heterozygosity (LOH) to be a poor prognostic factor at diagnosis of osteosarcoma (OS). It remains unclear whether LOH of the RB gene is suitable as a prognostic factor at diagnosis in patients with osteosarcoma. In this study we ai...

Proper regulation of cellular proliferation is critical for normal development and cancer prevention. Most, if not all, cancer cells contain mutations in the Rb/E2F pathway, which controls cellular proliferation. Inactivation of the retinoblastoma (Rb) family of proteins can occur through Rb loss, mutation, or inactivation by cellular or viral oncoproteins leading to unrestrained proliferation ...

We study the residual bootstrap (RB) method in the context of high-dimensional linear regression. Specifically, we analyze the distributional approximation of linear contrasts c(β̂ρ − β), where β̂ρ is a ridge-regression estimator. When regression coefficients are estimated via least squares, classical results show that RB consistently approximates the laws of contrasts, provided that p n, where t...