We report a high-resolution time series study of transcriptome dynamics following antimiR-mediated inhibition of miR-9 in a Hodgkin lymphoma cell-line-the first such dynamic study of the microRNA inhibition response-revealing both general and specific aspects of the physiological response. We show miR-9 inhibition inducing a multiphasic transcriptome response, with a direct target perturbation ...

This study examines the effect of response readiness on the stopping of motor responses. Thirteen subjects performed a primary task requiring a speeded choice reaction on go trials and response inhibition on nogo trials. An occasional cue informed subjects that a nogo trial was imminent but left them uncertain about the number of go trials separating the cue and the upcoming nogo trial. This se...

PURPOSE Mammographic breast density (MBD) is decreased by tamoxifen, but the effect of aromatase inhibitors is less clear. EXPERIMENTAL DESIGN We enrolled early-stage postmenopausal patients with breast cancer initiating adjuvant aromatase inhibitor therapy and ascertained mammograms before and at an average 10 months of aromatase inhibitor therapy. We matched cases to healthy postmenopausal ...

The inhibition of a prepotent response is an essential executive function which enables us to suppress inappropriate actions in a given context. Individuals with fencing expertise exhibit behavioral advantages on tasks with high demands on response inhibition. This study examines the electrophysiological basis for the superior response inhibition in experienced fencers. In the Go/Nogo task wher...

We report a facilitatory role of inhibitory synaptic input that can enhance a neuron's firing rate, in contrast to the conventional belief that inhibition suppresses firing. We study this phenomenon using the Hodgkin-Huxley model of spike generation with random Poisson trains of subthreshold excitatory and inhibitory inputs. Enhancement occurs when, by chance, brief inhibition leads excitation ...

The research reviewed in this article has investigated with behavioural, electrophysiological, and functional imaging methods how subliminally presented masked prime stimuli affect response-related processes. An initial response activation triggered by these primes was found to be followed by an inhibition of this response tendency, provided that the initial activation was strong enough to exce...

Psychological research has placed great emphasis on inhibitory control due to its integral role in normal cognition and clinical disorders. The stop-signal task and associated measure--stop-signal reaction time (SSRT)--provides a well-established paradigm for measuring response inhibition. However, motivational influences on stop-signal performance and SSRT have not been examined. We conceptual...

Comment on: Takagi S, Banno H, Hayashi A, Tamura T, Ishikawa T, Ohta Y. HER2 and HER3 cooperatively regulate cancer cell growth and determine sensitivity to the novel investigational EGFR/HER2 kinase inhibitor TAK-285. Oncoscience. 2014; 1:196-204.

aim and background: the behavioral inhibition system (bis) and the behavioral activation system (bas) are considered as factors to verify the effects of personality significance on cortical activity. the present study explored the effects of the bis and bas on frontal asymmetry in response to affect stimuli. methods and materials: this study included 36 individuals (18 with high bas sensitivity...

objective(s):one strategy for the treatment of diabetes is inhibition of pancreatic α- amylase. plants contains different chemical constituents with potential for inhibition of α-amylase and hence maybe used as therapeutic. materials and methods: urtica dioica and juglans regia linn were tested for α-amylase inhibition. different concentrations of leaf aqueous extracts were incubated with enzym...