RIGGI, S. J. AND N. R. DI LUZIO. Identification of a reticuloenduthelial stimulating agent in zymosan. Am. J. Physiol. zoo(z) : 297-300. 1961. -The functional activity of the reticuloendothelial system (RES), as determined by the intravascular clearance of colloidal carbon, and the degree of induced RE hyperplasia were studied following the intravenous injection of various constituents of zymos...

Kupffer cell and hepatocyte function were studied in 36 patients with fulminant hepatic failure by measurement of clearance of 125I microaggregated albumin (125IMAA) and galactose, respectively. Both were impaired but there was no correlation with final outcome, although on sequential testing 48 hours later, those patients who survived had a significantly greater improvement in Kupffer cell and...

Rats were injected intravenously with various particulate materials with and without the addition of various stabilizing agents. One hour after the injection of the blockading colloid, a tracer dose of similar or different colloidal material was injected. A half-time clearance rate of the tracer dose greater than 4 minutes was taken as evidence of blockade of the RES. Blockade of the tracer dos...

Effects of cyclophosphamide immunosuppressive therapy upon reticuloendothelial function in the rat have been studied. Numerous side effects including leukopenia, hematuria, diarrhea, hemorrhagic cystitis, and petechial hemorrhage in the lungs and the small bowel were observed. Studies utilizing (32)P-labeled bacteria revealed no change in the ability of the liver, spleen, lungs, or kidneys to i...