PURPOSE To assess the effect of ocular media opacity on retinal nerve fiber layer (RNFL) thickness measurements by optical coherence tomography (OCT). METHODS In this prospective, non-randomized clinical study, ocular examinations and OCT measurements were performed on 77 cataract patients, 80 laser refractive surgery patients and 90 patients whose signal strength on OCT was different on two ...

PURPOSE To document the existence of idiopathic bilateral optic atrophy (BOA) in rhesus macaque monkeys and to characterize the structural and functional consequences of this condition. METHODS In vivo assessment of retinal and optic nerve structure included fundus biomicroscopy and stereophotography. Functional analyses included transient pattern-reversal electroretinography (PERG) and full-...

1) Evaluation of the Optic Nerve requires descriptive quantitative and qualitative intrapapillary and parapapillary regions of the optic nerve head and the retinal nerve fiber layer (RNFL)variables including: a. Size and shape of the optic disc b. Size, shape and pallor of the neuroretinal rim c. Configuration and depth of the optic cup d. Cup-disc diameter ratio and cup-disc area ratio e. Posi...

OBJECTIVE To assess possible differences in the retinal nerve fiber layer (RNFL) thickness between children with strabismus and controls. This study also compared esotropia with exotropia cases, and dominant eyes with non-dominant eyes. METHOD 31 children with esotropia, 17 children with exotropia and 32 controls were studied. The peripapillary RNFL average thickness was determined in 4 diffe...

Purpose To compare the structure-function relationships between retinal nerve fiber layer thickness (RNFLT) and visual field defects measured either by standard automated perimetry (SAP) or by Pulsar perimetry (PP). Materials and Methods 263 eyes of 143 patients were prospectively included. Depending on the RNFLT, patients were assigned to the glaucoma group (group A: RNFL score 3-6) or the c...

INTRODUCTION Neurodegeneration is an early component of diabetic retinopathy (DR). It is unclear whether neurodegeneration is an independent factor or a consequence of damaged retinal vasculature. The aims of this study were to review the literature concerning neurodegeneration in diabetic patients without or with early DR, and to examine whether neurodegeneration precedes visible vasculopathy ...

This study was to analyse the degeneration of the Retinal Nerve Fiber Layer (RNFL) and optic disc and the relationship between optic nerve damage and the severity of cognitive impairment in patients with Alzheimer’s disease (AD) and Mild Cognitive Impairment (MCI). The RNFL thickness and optic disc variables were assessed by optical coherence tomography in patients with MCI and AD and control s...

PURPOSE To investigate the relationship between retinal nerve fiber layer (RNFL) thickness and retinal pigment epithelium alterations in patients with advanced glaucomatous visual field defects. METHODS A consecutive, prospective series of 82 study eyes with primary open-angle glaucoma and advanced glaucomatous visual field defects were included in this study. All study participants underwent...

OBJECTIVE Retinal nerve fiber layer (RNFL) loss occurs with MS or after optic neuritis. Acute RNFL alterations at presentation and changes over time have not been well documented. We analyzed regional RNFL changes using 2 methods, ocular coherence tomography (OCT) and scanning laser polarimetry (SLP), to study initial edema and early RNFL loss. METHODS 40 subjects with unilateral acute optic ...