نتایج جستجو برای: rhenium 186
تعداد نتایج: 10553 فیلتر نتایج به سال:
On-demand production of hydrogen from ammonia is a challenge limiting the implementation as long term vector to overcome difficulties associated with storage. Herein, we present development catalysts for on-demand by combining metals high and low N-adatom adsorption energies. In this way, cobalt-rhenium (Co-Re) show activity mimicking that ruthenium. EXAFS/XANES analyses demonstrate bimetallic ...
Ab initio MD and potential energy surface sampling has been used to study the rearrangement processes in carboranes and their derivatives. A new mechanism is found, in addition to those previously proposed. The fact that theoretical activation energies are lower than those observed experimentally, and the differing activity of technetium and rhenium complexes, are rationalised by orbital symmet...
Previous studies have shown that microRNA-186 (miR-186) is overexpressed in various human cancers and is associated with the regulation of the carcinogenic processes. However, the underlying mechanisms of this microRNA in melanoma remain largely unknown. In the present study, the overexpression of miR-186 was identified in melanoma tissues and melanoma cells compared to the expression of miR-18...
Recent evidence shows that miRNAs are dysregulated in a variety of cancers including gastric cancer (GC), and emerging as key oncogenes or tumor suppressors. In this study, qRT-PCR was used to analyze the expression of miR-186 in GC tissues and adjacent non-cancerous tissues, and then more in-vitro experiments were used to investigate the role of miR-186 in GC cells. Here, we identified miR-186...
As part of its responsibilities under various Acts of Parliament, MAFF Directorate of Fisheries Research has a duty to carry out a substantial programme of monitoring, surveillance and research in relation to the quality of the aquatic environment in and around the United Kingdom. In the course of that programme, a wide variety of methods of analysis are used for a wide variety of contaminants,...
The Kv1.3 channel is a recognized target for pharmaceutical development to treat autoimmune diseases and organ rejection. ShK-186, a specific peptide inhibitor of Kv1.3, has shown promise in animal models of multiple sclerosis and rheumatoid arthritis. Here, we describe the pharmacokinetic-pharmacodynamic relationship for ShK-186 in rats and monkeys. The pharmacokinetic profile of ShK-186 was e...
Deeper mechanistic understanding of lung adenocarcinoma (non–small cell lung carcinoma, or NSCLC), a leading cause of cancer-related deaths overall, may lead to more effective therapeutic strategies. In analyzing NSCLC clinical specimens and cell lines, we discovered a uniform decrease in miR-186 (MIR186) expression in comparisonwithnormal lung tissue or epithelial cell lines.miR-186 expression...
BACKGROUND Recent studies have shown that microRNAs may regulate the ABCB1 gene (ATP-binding cassette, sub-family B [MDR/TAP], member 1). Computational programs have predicted that the 3'-untranslated region (3'-UTR) of ABCB1 contains a potential miRNA-binding site for miR-186. Here, we investigated the role of miR-186 in sensitizing ovarian cancer cells to paclitaxel and cisplatin. RESULTS H...
The title compound, C(10)H(10)N(2)O, known as Edaravone (MCI-186), was crystallized from methanol. The two independent mol-ecules in the asymmetric unit are linked through an O-H⋯O hydrogen bond. One mol-ecule adopts a ketone form, while the other adopts an enol form. In the crystal structure, mol-ecules are linked through inter-molecular N-H⋯O hydrogen bonds, forming chains running along the b...
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