BACKGROUND Riboflavin finds ubiquitous occurrence in plants and animals and functions as a coenzyme participating in various oxidation-reduction reactions during the course of metabolism. Photosensitized riboflavin generates reactive oxygen species (ROS). Aminophylline is an antiasthmatic drug and a known phosphodiesterase inhibitor. In this study we examined the effect of photoilluminated ribo...

A number of chemical methods have been described for the determination of riboflavin (1-13). These methods are in general limited in use because, when applied to certain products, either they are not specific for riboflavin or all the riboflavin present is not recovered (2). In most cases the authors of papers presenting riboflavin methods have indicated that the methods are of limited applicat...

This is a record of the effects of feeding galactoflavin on the concentrations of riboflavin-containing coenzymes and enzymes in liver and kidney. Galactoflavin was shown by Emerson, Wurte, and Johnson (1) to produce a riboflavin deficiency in rats which is reversible by excess dietary riboflavin. Slight inhibitory effects of galactoflavin were later found by Kearney (2) on the enzymatic activi...

Considerable interest has been centered on Ashbya gossypii recently because of its ability to synthesize large quantities of riboflavin. The work of Wickerham, Flickinger, and Johnson (1946) called attention to the potential industrial significance of certain strains for the manufacture of riboflavin. During the course of studies on the synthesis of riboflavin it became of importance to leam so...

nafion is a perfluorinated anionic polyelectrolyte. the increasing popularity of nafion for the fabrication of redox polymer modified electrodes in recent years arises from easy fabrication, good electrical conductivity and high partition coefficients of many redox compounds in nafion. to investigate the production of nano-compositions by mixing electron transfer material and nafion polymer for...

Riboflavin, the biosynthetic precursor of the 5,6-dimethylbenzimidazole moiety of vitamin B12, is transformed non-enzymatically into 5,6-dimethylbenzimidazole in small yield on treatment with 1 N or 5 N NaOH at 100 degrees C. Besides 5,6-dimethylbenzimidazole 1,2-diamino-4,5-dimethylbenzene, 1,2-dihydro-6,7-dimethyl-2-keto-1-D-ribityl-3-quinoxaline carboxylic acid and N-1-D-ribitylamino-2-amino...

In order to study Staphylococcus epidermis and Staphylococcus aureus in vitro viability after the exposure to ultraviolet (UV) light and riboflavin, twelve strains of Staphylococcus epidermis and twelve strains of Staphylococcus aureus were isolated from patients with bacterial keratitis. The growth situation of Staphylococcus epidermidis and Staphylococcus aureus under different experimental c...

BACKGROUND Cisplatin is an effective anticancer drug that elicits many side effects mainly due to induction of oxidative and nitrosative stresses during prolonged chemotherapy. The severity of these side effects consequently restricts its clinical use under long term treatment. Riboflavin is an essential vitamin used in various metabolic redox reactions in the form of flavin adenine dinucleotid...

Riboflavin deficiency in weanling rats causes a metabolic disorder characterized by failure to oxidize fatty acids. The disorder is similar to that seen in several human diseases, some of which are responsive to pharmacological doses of riboflavin. Previous analysis of the riboflavin-deficient rat has shown that the failure of fatty acid oxidation is due to a decrease in the activity of the acy...

C20orf54 is a riboflavin transporter gene that involved in the intestinal absorption of riboflavin, which is required for normal cellular functions in all aerobic forms of life. The posttranscriptional regulation of C20orf54 expression and its association with epigenetic modifications in cancer development remain unclear. We aimed to study C20orf54 hypermethylation and its regulation on C20orf5...