A total of 123 patients with moderately advanced, cavitary lung disease caused by Mycobacterium avium complex untreated previously received different regimens of antituberculosis agents. The rate of sputum conversion (continuously negative cultures for six months or more) was compared among the regimens. It was shown that the regimens of rifampin + isoniazid + streptomycin and rifampin + isonia...

Eradication of Staphylococcus aureus biofilms after rifampin treatment was tested in a mouse model of device-related infection by using biophotonic imaging. Following treatment, the bioluminescent signals decreased to undetectable levels, irrespective of the age of the biofilm. After the final treatment, the signals rebounded in a time-dependent manner and reached those for the untreated mice. ...

background : republic of azerbaijan is considered as an area with high prevalence of multi-drug resistant tuberculosis. uncontrolled travelling of azerbaijanis people to iran is the issue that needs to be considered as an important issue. methods : this study was conducted on 32 patients with tuberculosis from baku–nakhchivan and 48 patients from iran during 2012 to 2014. colonies of mycobacter...

backgrounds and objectives : ganoderic acids are the most valuable secondary metabolites in ganoderma lucidum traditional medicinal mushrooms, which have shown antitumor properties in many studies. however, application of ganoderic acids is limited due to low yield production. recently, it was shown that static liquid culture could be a proven technology for producing ganoderic acids in ganoder...

the multiple etiologic factors involved in acne make the use of various medications necessary to treat the condition. this study aimed to determine the efficacy of mupirocin and rifampin used with standard treatment in the management of acne vulgaris. in a multicentre, randomized controlled, triple-blinded study, a total of 105 acne patients, with a clinical diagnosis of moderate to severe acne...

Abstract Interest has grown in less invasive surgical treatment and early use of oral antibiotics the C. acnes prosthetic joint infection (PJI). We report a series patients who were successfully treated with single-stage exchange an all-oral course rifampin linezolid.

Reverse transcription-polymerase chain reaction (RT-PCR) and quantitative, competitive RT-PCR were used to examine the capability of rifampin to induce the expression of mRNA derived from multidrug resistance-1 (MDR1) and drug-metabolizing cytochrome P450 (P450) genes in the mononuclear fraction (lymphocytes) of human blood. A total of 50 healthy volunteers (age, 18-74) participated in two stud...

BACKGROUND Rifampin and pyrazinamide are recommended for treatment of latent tuberculosis infection in adults without HIV infection, but reports of severe hepatotoxicity have raised concerns about its safety. Clinical trials have not compared this treatment with isoniazid in adults without HIV infection. OBJECTIVE To compare the safety and tolerance of a 2-month regimen of rifampin and pyrazi...

The organic anion transporting polypeptide 1B1 (OATP1B1, encoded by SLCO1B1) plays an important role in the transport of endogenous and xenobiotic compounds, such as bile acids and rifampin. In this study, the association between OATP1B1 polymorphisms and rifampin hepatotoxicity was investigated using integrated population genetic analysis and functional studies. A total of 273 unrelated patien...

BACKGROUND There is conflicting data regarding the efficacy of tulathromycin for the treatment of foals with bronchopneumonia. HYPOTHESES Tulathromycin is effective for the treatment of bronchopneumonia in foals and noninferior to the combination of azithromycin and rifampin. ANIMALS A total of 240 foals on a farm endemic for infections caused by Rhodococcus equi. METHODS In a controlled,...