The goal of this research is to determine the feasibility of loading rifampin into mesoporous silica nanoparticles. Rifampin was selected as a model lipophilic molecule since it is a well-documented and much used anti tuberculosis drug. The mesoporous silica nanoparticles were prepared by using Tetraethyl ortho silicate and cetyltrimethyl ammonium bromide (as surfactant); The prepared nanoparti...

Staphylococcus aureus is a common cause of native valve infective endocarditis (IE). Rifampin is often added to traditional therapy for the management of serious S. aureus infections. There are no large, prospective studies documenting the safety and efficacy of adjunctive therapy with rifampin for treatment of native valve S. aureus IE. We reviewed all cases of definite native valve S. aureus ...

Among patients with tuberculosis, rifampin plasma concentrations and sputum conversion rates have been reported to be lower in Africans. Rifampin is a substrate of P-glycoprotein (coded for by the ABCB1 gene) and organic anion-transporting polypeptide 1B1 (coded for by SLCO1B1). The objectives were to identify genetic polymorphisms of drug transporters and the transcriptional regulators pregnan...

BACKGROUND Rifampin is used as adjunctive therapy for Clostridium difficile-associated disease, and the drug's derivative, rifaximin, has emerged as an attractive antimicrobial for treatment of C. difficile-associated disease. Rifampin resistance in C. difficile strains has been reported to be uncommon. METHODS We examined the prevalence of rifampin resistance among 470 C. difficile isolates ...

The authors present general considerations and simple models for the operation of isothermal motors at small scales, in asymmetric environments. Their work is inspired by recent observations on the behavior of molecular motors in the biological realm, where chemical energy is converted into mechanical energy. A generic Onsager-like description of the linear (close to equilibrium) regime is pres...

1. In a recent paper [1] a well resolved rotational structure has been observed in the infra-red spectrum of the linear OCS molecule embedded in a He cluster at T<Tλ. In fact, this group has observed this phenomenon earlier on the example of the SF6 molecule [2] but with less resolution. However, the most impressive and interesting aspect is the observation in the same work [1] that the rotatio...

background:chronic synovitis is one of the most important complications in haemophilic patients. rifampin is anantibiotic which its intra-articular injecion leads to destruction of the synovial membrane of haemophilic patientsmedically.materials and methods: between september 2003 and november 2005, we administered intra-articular rifampinin ١۶ haemophilic joints of ٨ haemophilic patients.resul...

Identification of Mycobacterium tuberculosis and Rifampin Resistance in Pulmonary Extra-pulmonary Clinical Specimens Using the Gene Xpert MTB/RIF Assay