Chromosome segregation is triggered when the ring-shaped chromosomal cohesin complex is opened by proteolytic cleavage to release pairs of sister chromatids. Even before this dramatic event in anaphase, many cohesin rings lead a dynamic life on chromosomes, and in metazoan cells a good part of them dissociate from chromosome arms during mitotic prophase. Two new papers in The EMBO Journal addre...

In the title compound, C(13)H(9)ClN(2)O(5)S, the dihedral angle between the two rings is 71.2 (1)°. The crystal structure features inversion dimers linked by pairs of N-H⋯O(S) hydrogen bonds.

Let i : A → R be a ring morphism, and χ : R → A a right R-linear map with χ(χ(r)s) = χ(rs) and χ(1 R) = 1 A. If R is a Frobenius A-ring, then we can define a trace map tr : A → A R. If there exists an element of trace 1 in A, then A is right FBN if and only if A R is right FBN and A is right noetherian. The result can be generalized to the case where R is an I-Frobenius A-ring. We recover resul...

Ring chromosomes in man, in association with congenital abnormalities, have been reported involving a chromosome in the I7-I8 group (Genest, Leclerc, and Auger, I963; Gropp, Jussen, and Ofteringer, I964; Lucas, Kemp, Ellis, and Marshall, I963; Wang, Melnyk, McDonald, Uchida, Carr, and Goldberg, I962), a chromosome in the X-6-I2 group which is probably not an X (Turner, I963), a member of the I3...

The so-called Philadelphia (Ph) chromosome is present in more than 90% of chronic myeloid leukemia (CML) cases. It results in juxtaposition of the 5' part of the BCR gene on chromosome 22 and the 3' part of the ABL1 gene on chromosome 9. An additional acquired monosomy 7 or deletion of 7q is associated with poor prognosis in a variety of myeloid disorders. Here we report a novel Ph chromosome p...

Six cases of epilepsy associated with ring chromosome 20 are presented. The study of these cases and 20 cases reported in the literature revealed that they constitute a distinct epileptic syndrome: frequent seizures consisting of a prolonged confusional state, with or without additional motor seizures, and an ictal EEG pattern of long-lasting bilateral paroxysmal high-voltage slow waves with oc...

The ring chromosome 20 syndrome is a rare syndrome characterized by intractable epilepsy with particular electro clinical features including episodes of prolonged confusional state and nocturnal frontal lobe seizures. We report a 17-year-old girl who had intractable epilepsy with frontal seizure and prolonged confusional state secondary to non-convulsive status epilepticus. The diagnosis of rin...