OBJECTIVES In the last decade there have been numerous randomized controlled trials comparing the efficacy and safety of second generation antipsychotics and conventional antipsychotics in the treatment of schizophrenia, but most of them have been conducted in the western population. This study compared the efficacy and safety of risperidone versus haloperidol in the Nepalese context, in order ...

BACKGROUND Increased serum prolactin and weight gain are common side effects of atypical antipsychotics but few studies have assessed the long-term pattern of these adverse effects. AIM Compare the effects of risperidone and quetiapine on serum prolactin and weight over 12 months of treatment among female patients with first-episode schizophrenia. METHODS Eighty female inpatients with first...

a simple, rapid and sensitive high-performance liquid chromatographic (hplc) method for the determination of risperidone in human plasma was developed. an hplc system based on a nucleosil c8 column (150?4 mm) and a uv detector (?= 280 nm) were used. a mixture of sodium dihydrogen phosphate buffer-acetonitrile (55:45, v/v) adjusted to ph 6.0 at a flow rate of 1.5 ml min-1 was used as mobile phas...

objective: although sodium valproate came to the market as an anticonvulsant drug, nowadays it's wildly used in the management of psychiatric disorders. it is used as a mood stabilizer and as an adjunctive agent in treatment of depression and psychosis. there are controversies regarding sodium valproate efficacy in psychosis. although some studies have reported that it is effective in the ...

This is a review of the clinical trials investigating the efficacy and safety of risperidone in the treatment of children with autistic spectrum disorders (ASD). The main clinical characteristics are impairment in social skills, communication difficulties, repetitive movements and behaviors, including stereotypies. Pharmacotherapy is mainly directed at the so-called target symptoms, ie, behavio...

The authors sought to give a perspective of the local use of two atypical neuroleptics which may represent a new era in the treatment of schizophrenia. The findings from local drug trials and clinical reports are summarised. Both clozapine and risperidone are efficacious in reducing the psychotic symptomatology of schizophrenia as well as inducing less extrapyramidal side-effects. Differences i...

ackground: Risperidone has been shown to be clinically effective for the treatment of aggressive behavior in children, yet no information s available regarding whether risperidone exhibits aggression-specific suppression in preclinical studies that use validated developmentally mmature animal models of escalated aggression. Previously, we have shown that exposure to low doses of the psychostimu...

Forty four schizophrenic patients were randomly assigned to receive risperidone in 4-8 mg doses either once daily or twice daily for 8 weeks. An open trial was conducted to determine the efficacy of once daily administration of risperidone as compared to twice daily administration. Assessment were done on Positive and Negative Syndrome Scale (PANSS) and Clinical Global Impression (CGI) scale Ei...