PURPOSE We report the role of relative lymphocyte count (RLC) as a potential biomarker with prognostic impact for catumaxomab efficacy and overall survival (OS) based on a post hoc analysis of the pivotal phase II/III study of intraperitoneal catumaxomab treatment of malignant ascites. EXPERIMENTAL DESIGN The impact of treatment and RLC on OS was evaluated using multivariate Cox models. Kapla...

Organic neuromorphic devices mimic signal processing features of biological synapses, with short-term plasticity, STP, modulated by the frequency input voltage pulses. Here, an artificial synapse, made intracortical microelectrodes, is demonstrated that exhibits either depressive or facilitative STP. The crossover between two STP regimes controlled voltage. are described equivalent circuit wher...

Skeletal muscle, during periods of exertion, experiences several different fatigue-based changes in contractility, including reductions in force, velocity, power output, and energy usage. The fatigue-induced changes in contractility stem from many different factors, including alterations in the levels of metabolites, oxidative damage, and phosphorylation of the myosin regulatory light chain (RL...

In this paper, we investigate the benefits of applying a form of network coding known as Random Linear Coding (RLC) to unicast application in Disruption Tolerant Networks (DTNs). Under RLC, nodes store and forward random linear combinations of packets as they encounter each other. For the case of a single group of packets originating from the same source and destined for the same destination, w...

The interaction of a protein-bound polysaccharide (PSK) isolated from Basidiomycetes with smooth muscle myosin components was evaluated by limited digestion, urea/glycerol gel electrophoresis, affinity chromatography and overlay assay using a peptide array. PSK was bound to the regulatory light chain (RLC) of myosin, but not to the essential light chain. The binding to PSK was definitely observ...

Spectral techniques based on sinusoidal functions have a long and successful tradition in Signal Processing and in Communication Engineering. A mathematical reason is the fact that they constitute the eigenfunctions of linear operators which model by means of ordinary linear differential equations important physical building blocks for components and systems which are of practical importance th...

While transformer-type conductivity sensors are the usual type of inductive sensors, this paper describes theory behind less used eddy current sensors. This sensor measures a liquid by inducing currents and observing effect on coil, which allows simpler design promises cost advantage in implementation. A novel model description is derived from Maxwell equations implemented an equivalent RLC cir...

It is generally recognized that ventricular myosin regulatory light chains (RLC) are approximately 40% phosphorylated under basal conditions, and there is little change in RLC phosphorylation with agonist stimulation of myocardium or altered stimulation frequency. To establish the functional consequences of basal RLC phosphorylation in the heart, we measured mechanical properties of rat skinned...

In performance-driven interconnect design, delay estimators are used to determine both the topol-ogy and the layout of good routing trees. We address the class of moment-matching methods used to model distributed RLC interconnects with a small number of lumped segment models. We provide new non-uniform segment models which match the transfer function of a general interconnect line with source a...