Rho-associated kinase (ROCK) I mediates signaling from Rho to the actin cytoskeleton. To investigate the in vivo functions of ROCK-I, we generated ROCK-I-deficient mice. Loss of ROCK-I resulted in failure of eyelid closure and closure of the ventral body wall, which gave rise to the eyes open at birth and omphalocele phenotypes in neonates. Most ROCK-I(-/-) mice died soon after birth as a resul...

27 Using projective and objective measures, effects of rock music on emotion were investigated. Sixty students were randomly assigned to three conditions: hard rock, soft rock, and no music. One group listened to hard rock music while taking a projective test with five ink blots and an objective test with an Emotional Assessment Scale (EAS). The same procedure was used for the second group whil...

In this paper, a practical project of subway tunnel lining demolition via blasting for the construction station under action load and weight collapsed rock mass was proposed. The overbreak underbreak quality, failure mechanism structure, particle peak velocity (PPV), stress evolution law surrounding caused by were researched using LS-DYNA. Firstly, results show that parameters presented in pape...

The homologous mammalian rho kinases (ROCK I and II) are assumed to be functionally redundant, based largely on kinase construct overexpression. As downstream effectors of Rho GTPases, their major substrates are myosin light chain and myosin phosphatase. Both kinases are implicated in microfilament bundle assembly and smooth muscle contractility. Here, analysis of fibroblast adhesion to fibrone...

The evaluation of local stability of the tunnel surrounding rock mass with weak rock layer is very important for the economy and security of the tunnel construction. Based on the rock tunnel geological conditions in the construction, the finite element model of the tunnel surrounding rock mass stability analysis with weak rock layer is established in the article by selecting the ABAQUS program ...

In terms of target detection and classification, scattering from exposed rock on the seafloor, (i.e., individual rocks and rock outcrops) presents some of the most difficult challenges for modern MCM and ASW sonar systems in shallow water. Work on characterizing, modeling and simulating mean levels and other statistical measures of acoustic scattering from rocks and rock outcrops is therefore c...

Axonal injury due to prostatectomy leads to Wallerian degeneration of the cavernous nerve (CN) and erectile dysfunction (ED). Return of potency is dependent on axonal regeneration and reinnervation of the penis. Following CN injury (CNI), RhoA and Rho-associated protein kinase (ROCK) increase in penile endothelial and smooth muscle cells. Previous studies indicate that nerve regeneration is ham...

The following article analyzes the effectiveness of directional hydraulic fracturing (DHF) as a method rock burst prevention, used in black coal mining with longwall system. In order to define changes seismic activity due DHF at “Rydułtowy” Black Coal Mine (Upper Silesia, Poland), observations were made regarding mass during system using roof layers collapse. was recorded area itself, where, on...

The purpose of the paper was to identify causes rock bumps that occurred at Alardinskaya mine (Russia) in 2011. research carried out using finite element method. developed three-dimensional model mass included a coal seam, rocks bedding above and below, goaf, system local preparatory workings. situation arose immediately before first burst modeled during - when longwall crossed diagonal entry. ...