Rho-kinase (ROCKs) is an important downstream effector of the small GTP-binding protein Ras homolog gene family member A. There are 2 isoforms of ROCK, ROCK1 and ROCK2, and they have different functions in several vascular components. The Ras homolog gene family member A/ROCK pathway plays an important role in various fundamental cellular functions, including contraction, motility, proliferatio...

The Imager for Mars Pathfinder (IMP) was a mast-mounted instrument on the Mars Pathfinder lander which landed on Mars’ Ares Vallis floodplain on July 4, 1997. During the 83 sols of Mars Pathfinders landed operations, the IMP collected over 16,600 images. Multispectral images were collected using twelve narrowband filters at wavelengths between 400 and 1000 nm in the visible and near infrared (V...

1.INTRODUCTION Some forty years ago, most opening supports and reinforcements were designed using empirical rules defining ground loads acting on the supporting structures. This approach is still popular and interest in it has been renewed by the use of rock mass classification systems (Barton et al. 1974, Bieniawski, 1974,1976,1989). Correlations between rock mass conditions and the type of su...

Data on discontinuities are always necessary for design, characterization and analysis of rock structures. The time honored method of manual measurements with Brunton compass is both time consuming and often inconvenient given issues such as restricted access to measurement areas, introduction of erroneous data due to sampling difficulties and human bias, considerable safety risks since measure...

Under low confinement axial compression, the failure of brittle rock is mainly caused by tensile fracture. Many scholars adopt sliding crack as an idealized model to present intrinsic mechanism but due complex configuration crack, its stress intensity factor (SIF) calculation has always been a difficult problem. In this study, improved proposed; in context linear elastic fracture mechanics (LEF...

In order to strengthen the prediction of rockburst and inquire the relationship between the rockburst proneness of rock and its surface fractal characteristic, the surface fractal of the rock was studied by fractal method and uniaxial compression test. The change rules of surface fractal of different types of rock were compared by calculating its fractal dimension of rock before experiment and ...

Cristae in crisis ristae, the complex involutions of the mitochondrial inner membrane, vastly increase the surface area across which ATP synthase can generate a proton gradient. Now, new findings from Jean Velours (Université Victor Ségalen, Bordeaux, France) and colleagues suggest that ATP synthase may be important in forming cristae in the first place. Velours' theory is that oligomerization ...

The CC chemokine eotaxin plays a pivotal role in local accumulation of eosinophils. Very little is known about the eotaxin signaling in eosinophils except the activation of the mitogen-activated protein (MAP) kinase family. The p21 G protein Rho and its substrate Rho-associated coiled-coil forming protein kinase (ROCK) regulate the formation of stress fibers and focal adhesions. In the present ...

Idiopathic pulmonary fibrosis (IPF) is characterized by progressive lung scarring, short median survival, and limited therapeutic options, creating great need for new pharmacologic therapies. IPF is thought to result from repetitive environmental injury to the lung epithelium, in the context of aberrant host wound healing responses. Tissue responses to injury fundamentally involve reorganizatio...

Rho-associated kinases (ROCKs) are critical molecules involved in the physiological functions of macrophages, such as chemotaxis and phagocytosis. We demonstrate that macrophage adherence promotes rapid changes in physiological functions that depend on translational upregulation of preformed ROCK-1 mRNA, but not ROCK-2 mRNA. Before adherence, both ROCK mRNAs were present in the cytoplasm of mac...