Massively Multiplayer Online Role-Playing Games (MMORPGs) are very sophisticated applications, which have significantly grown in popularity since their early days in the mid-90s. Along with growing numbers of users the requirements on these systems have reached a point where technical problems become a severe risk for the commercial success. Within the CloudCraft project we investigate how Clou...

The dyslexia-associated gene DCDC2 is a member of the DCX family of genes known to play roles in neurogenesis, neuronal migration, and differentiation. Here we report the first phenotypic analysis of a Dcdc2 knockout mouse. Comparisons between Dcdc2 knockout mice and wild-type (wt) littermates revealed no significant differences in neuronal migration, neocortical lamination, neuronal cilliogene...

In future Ambient Intelligence environments we assume intelligence embedded in the environment and its virtual, sometimes visualized agents (virtual humans). These environments support the human inhabitants or visitors in their activities and interactions by perceiving them through their sensors. In this paper we look at our research on bodily and gestural interaction with environments equipped...

We have observed the massive star forming region, IRAS18507+0121, at millimeter wavelengths in 3 mm continuum emission and HCO(J=1–0) and SiO(v=0, J=2–1) line emission, and at near-infrared wavelengths between 1.2 and 2.1μm. Two compact molecular cores are detected: one north and one south separated by ∼ 40′′. The northern molecular core contains a newly discovered, deeply embedded, B2 protosta...

Evidence of technological performance, medical improvements and economic effectiveness is generally considered sufficient for judging advances in healthcare. In this paper, I aim to add knowledge about the ways human emotions and professional relations play roles in the processes of accommodating new technologies for quality improvements. A newly-implemented, web-based ulcer record service for ...

In a capacitated network design game, each of n players selects a path from her source to her sink. The cost of each edge is shared equally among the players using the edge. Every edge has a finite capacity that limits the number of players using the edge. We study the price of stability for such games with respect to the max-cost objective, i.e., the maximum cost paid by any player. We show th...

Personalizing the playing experience is a key factor in making players of computer games feel involved in the virtual world; however, current Massively Multiplayer Online Role Playing Games only to a limited degree allocate development or running resources towards facilitating a personalized experience. In Pen and Paper Role Playing Games, the player-controlled characters form a key component i...

Observations going back more than 20 years show that regions in proteins with disordered backbones can play roles in their binding to other molecules; typically, the disordered regions become ordered upon complex formation. Thought-experiments with Schulz Diagrams, which are defined herein, suggest that disorder-to-order transitions are required for natural selection to operate separately on af...

HMGN (high-mobility-group N) family members are vertebrate proteins that unfold chromatin and promote transcription and replication of chromatin templates in vitro. However, their precise roles in vivo have been elusive until recently. This paper summarizes recent advances from studies of Hmgn1 knockout mice and genetically engineered cell lines that are beginning to reveal the diverse roles th...

BACKGROUND Colour is a consequence of the optical properties of an object and the visual system of the animal perceiving it. Colour is produced through chemical and structural means, but structural colour has been relatively poorly studied in plants. SCOPE This Botanical Briefing describes the mechanisms by which structures can produce colour. In plants, as in animals, the most common mechani...