Receptor-ligand bonds that mediate cell adhesion are often subjected to forces that regulate their dissociation via modulating off-rates. Off-rates control how long receptor-ligand bonds last and how much force they withstand. One should therefore be able to determine off-rates from either bond lifetime or unbinding force measurements. However, substantial discrepancies exist between the force ...

In this paper, we compare the effect of rolling resistance at the contacts in granular systems composed of disks with the effect of angularity in granular systems composed of regular polygonal particles. For this purpose, we use contact dynamics simulations. By means of a simple shear numerical device, we investigate the mechanical behavior of these materials in the steady state in terms of she...

In this study, the effect of cold rolling process on the microstructure and texture evolution in 1wt. % Si non-oriented electrical steel was investigated. For this purpose, all samples were processed through single-stage hot rolling at 1100 ° C and two-stage cold rolling (cross rolling and unidirectional rolling) with intermediate annealing at 650 °C for 35 seconds. Finally, all of them were fu...

A friction-variable touch panel is capable of presenting virtual bumps and holes on its flat surface through the control of the surface frictionwhen a fingertip slides over it. To improve thepresentation, we developed a friction model of a fingertip sliding over a sinusoidal surface with an amplitude of 0.5–2.5mm and a spatial wavelength of 20–50mm. When a metal ball rolls over a wavy surface w...

This paper focuses on the railway rolling stock circulation problem in rapid transit networks where the known demand and train schedule must be met by a given fleet. In rapid transit networks the frequencies are high and distances are relatively short. Although the distances are not very large, service times are high due to the large number of intermediate stops required to allow proper passeng...

Plastid genomes of peridinin-containing dinoflagellates are unique in that its genes are found on multiple circular DNA molecules known as 'minicircles' of approximately 2-3 kb in size, carrying from one to three genes. The non-coding regions (NCRs) of these minicircles share a conserved core region (250-500 bp) that are AT-rich and have several inverted or direct repeats. Southern blot analysi...

Machine learning concepts, such as the support vector machine (SVM), have been theoretically discussed in great detail, but in industrial applications still rather old-fashioned solutions are preferred. To show that learning concepts improve industrial planning, scheduling, and steering processes, a cooperation with a steel manufacturer was initiated to build a prototype pass schedule calculato...