High throughput genome wide associations studies (GWAS) are now identifying a large number of genome loci related to risk of common human disease. Each such locus presents a challenge in identifying the relevant underlying mechanism. Here we report the experimental characterization of a proposed causal single nucleotide polymorphism (SNP) in a locus related to risk of Crohn's disease and ulcera...

The process of alternative splicing is widely misregulated in cancer, but the contribution of splicing regulators to cancer development is largely unknown. In this study, we found that the splicing factor hnRNP A2/B1 is overexpressed in glioblastomas and is correlated with poor prognosis. Conversely, patients who harbor deletions of the HNRNPA2B1 gene show better prognosis than average. Knockdo...

Ulcerative colitis (UC) is a chronic, nonspecific, inflammatory disease for which an effective treatment is lacking. Our previous study found that Qingchang Wenzhong Decoction (QCWZD) can significantly improve the clinical symptoms of UC and ameliorate dextran sulphate sodium- (DSS-) induced ulcerative colitis in rats by downregulating the IP10/CXCR3 axis-mediated inflammatory response. The pur...

A 100-V Taper-Shielded trench Gate (TSG) power metal-oxide-semiconductor field-effect transistor (MOSFET) with superior figure-of-merit (FOM) is proposed and investigated in this paper. The gate of the TSG-MOSFET has a tapered shape to reduce gate-to-drain overlap capacitance (CGD) charge (QG). vertical drift region doping profile enhanced two ways. First use multi-step epitaxial growth produce...

Modern spark-ignition engines are knock-limited over a significant fraction of their operating map. The efficiency loss induced by knock mitigation depends on both the fuel octane quality and driving conditions. This paper quantifies relevance Research Octane Number (RON) Motor (MON) to losses (KLFEL) mid-size sports utility vehicle operated in several standard drive cycles. Index model, OI = (...

The 3rd Pacific Rim (‘‘PacRim’’) meeting on breast and prostate cancer on Fraser Island (Queensland, Australia) brought together a cast of international experts from October 31 to November 4, 2006. The meeting highlighted the current progress in breast and prostate cancer in the context of the enduring legacy of Ronald K. Ross in hormone-dependent cancer research. The overall thrust of this mee...

INTRODUCTION Radiation-induced optic neuropathy (RON) is an infrequent but devastating consequence of radiation exposure to the visual pathways, usually following months to years after the treatment of paranasal or intracranial tumours. Hyperbaric oxygen (HBO) therapy is one of several therapies that have been tried for this condition. The purpose of this review is to describe the clinical char...

Epithelial-to-mesenchymal transition (EMT) is an embryonic program used by cancer cells to acquire invasive capabilities becoming metastatic. ΔRon, a constitutively active isoform of the Ron tyrosine kinase receptor, arises from skipping of Ron exon 11 and provided the first example of an alternative splicing variant causatively linked to the activation of tumor EMT. Splicing of exon 11 is cont...

Our recent DNA microarray analysis using tissue obtained by laser capture microdissection (LCM) identified up-regulation of RON (a tyrosine kinase receptor) during the late secretory phase in eutopic endometrial epithelial cells from patients with deep endometriosis compared with control endometrium from women with macroscopically normal pelvic cavities. In the present study, we further investi...

The candidate tumor-suppressor gene hyaluronidase 2 (HYAL2) encodes a glycosylphosphatidylinositol-anchored cell-surface protein that serves as an entry receptor for jaagsiekte sheep retrovirus, a virus that causes contagious lung cancer in sheep that is morphologically similar to human bronchioloalveolar carcinoma. The viral envelope (Env) protein alone can transform cultured cells, and we hyp...