نتایج جستجو برای: ror1

تعداد نتایج: 253  

2015
Isabel Moreno-Indias Francisco José Tinahones

Obesity is considered a major health problem. However, mechanisms involved and its comorbidities are not elucidated. Recent theories concerning the causes of obesity have focused on a limit to the functional capacity of adipose tissue, comparing it with other vital organs. This assumption has been the central point of interest in our laboratory. We proposed that the failure of adipose tissue is...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2009
Jeffrey W Tyner Michael W Deininger Marc M Loriaux Bill H Chang Jason R Gotlib Stephanie G Willis Heidi Erickson Tibor Kovacsovics Thomas O'Hare Michael C Heinrich Brian J Druker

Targeted therapy has vastly improved outcomes in certain types of cancer. Extension of this paradigm across a broad spectrum of malignancies will require an efficient method to determine the molecular vulnerabilities of cancerous cells. Improvements in sequencing technology will soon enable high-throughput sequencing of entire genomes of cancer patients; however, determining the relevance of id...

2014
Graham R. D. McGrann Anna Stavrinides Joanne Russell Margaret M. Corbitt Allan Booth Laetitia Chartrain William T. B. Thomas James K. M. Brown

Ramularia leaf spot (RLS), caused by the fungus Ramularia collo-cygni, is a serious, recently emerged disease of barley in Europe and other temperate regions. This study investigated the trade off between strong resistance to powdery mildew conferred by mlo mutant alleles and increased susceptibility to RLS. In field trials and seedling tests, the presence of mlo alleles increased severity of R...

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