How to combine antirejection drugs and which is the optimal dose of steroids and calcineurin inhibitors beyond the first year after kidney transplantation to maintain adequate immunosuppression without major side effects are far from clear. Kidney transplant patients on steroid, cyclosporine (CsA), and azathioprine were randomized to per-protocol biopsy (n = 30) or no-biopsy (n = 29) 1 to 2 yr ...

This study sought to determine the extent to which GFR is decreased during acute renal allograft rejection in human subjects and to determine the mechanism of the decrease in GFR. Eight patients with biopsy-proven acute rejection were compared with 18 recipients of optimally functioning renal allografts. GFR and renal plasma flow (RPF) were measured as the clearance of inulin and para-aminohipp...

Experiments were performed to characterize renal hemodynamics in Thy-1 nephritic rats. A monoclonal antibody against Thy-1 was intravenously injected to induce mesangiolysis in rats, and 2 days later renal hemodynamic responses to variations in blood pressure were determined. In the first series of experiments, autoregulation of renal plasma flow (RPF) or glomerular filtration rate (GFR) was im...

BACKGROUND & OBJECTIVE Radiation pulmonary fibrosis (RPF) is characterized by fibroblast proliferation and excessive accumulation of extracellular matrix (ECM). Transforming growth factor beta (TGFbeta) is a switch factor in the initiation and development of RPF and serves as a therapeutic target. Blocking TGFbeta1 signal transduction pathway might alleviate RPF. This study was to investigate t...

Trained conscious mongrel dogs were used as the experimental animals. Arterial blood pressure was measured by means of a van Leersum carotid loop (3, 4). Renal plasma flow (RPF) and glomerular filtratration (GF) were determined by para-aminohippurate (PAH) and creatinine clearances, respectively. Filtration fraction (FF) was calculated from RPF and GF. Creatinine and PAH were administered intra...

Abnormal renal function is common in acute and chronic congestive heart failure (CHF) and is related to the severity of congestion. However, treatment of congestion often leads to worsening renal function. Our objective was to explore basal determinants of renal function and their response to hemodynamic interventions. Thirty-seven patients without CHF and 59 patients with chronic CHF (ejection...

This paper does not directly engage the state-formation, political settlement and state-building debates in Africa but it foregrounds notion of conversation as lens through which to examine Rwanda’s history. In particular, explores an overlooked perspective from trajectory by focusing on a particular class actors – women whose voices also contributed inter-elite elite-society pre-colonial times...

The residual agricultural plastic film in China is not easily recovered due to the thinness and poor mechanical properties of domestic films, a large amount remaining farmland soil poses great threat quality crop production. A spring-tooth collector (SRPFC) widely used (RPF) recycling operations. However, there are two major problems current SRPFC: low recovery rate (RRRF) caused by difficulty ...