نتایج جستجو برای: rs9939609 polymorphism

تعداد نتایج: 107470  

2009
Jian'an Luan Berit Kerner Jing-Hua Zhao Ruth JF Loos Stephen J Sharp Bengt O Muthén Nicholas J Wareham

Obesity has become an epidemic in many countries and is one of the major risk conditions for disease including type 2 diabetes, coronary heart disease, stroke, dyslipidemia, and hypertension. Recent genome-wide association studies have identified two genes (FTO and near MC4R) that were unequivocally associated with body mass index (BMI) and obesity. For the Genetic Analysis Workshop 16, data fr...

Journal: :PLoS ONE 2009
Laura Johnson Cornelia H. M. van Jaarsveld Pauline M. Emmett Imogen S. Rogers Andy R. Ness Andrew T. Hattersley Nicholas J. Timpson George Davey Smith Susan A. Jebb

BACKGROUND Dietary energy density (DED) does not have a simple linear relationship to fat mass in children, which suggests that some children are more susceptible than others to the effects of DED. Children with the FTO (rs9939609) variant that increases the risk of obesity may have a higher susceptibility to the effects of DED because their internal appetite control system is compromised. We t...

2009
SAILA LAAKSO

Premature adrenarche (PA) is defined as adrenarcheal levels of adrenal androgens before the age of 8 yrs in girls and the age of 9 yrs in boys leading to androgenic signs ranging from pubarche to oily skin and adult type body odor. PA has been connected with adverse metabolic features and increased risk for ovarian hyperandrogenism. The pathogenesis of PA is considered polygenic. However, under...

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