Dengue is the most important mosquito-borne viral disease in world. In 2017, a concerning increase dengue cases with high mortality was seen India Kerala topping list. Changing pattern of circulating virus serotype and co infection multiple serotypes contribute to increasing trend severity increased fever. The present study focused find prevalent central prevalence here an attempt correlate the...

Objectives: A retrospective study was carried out to assess the performance of hepatitis C diagnostic assays in our laboratory, and to determine the prevalence of hepatitis C among blood donors at the Sultan Qaboos University Hospital. Methods: From 1991 to 2001, approximately 55,000 serum samples collected from blood donors and patients were submitted to our laboratory for testing. All sera we...

BACKGROUND Semaphorins act as chemotactic cues for cell movement via their transmembrane receptors, plexins. Somatic missense mutations in the plexinB1 gene coupled with overexpression of the protein frequently occur in prostate tumors, indicating a role for plexinB1 in the pathogenesis of prostate cancer. However, the effect of semaphorin/plexin signaling is highly context dependent and whethe...

Carpenter RL, Lemmer JT, Francis RM, Knous JL, Sarzynski MA, Womack CJ. Tissue Plasminogen Activator And Plasminogen Activator Inhibitor-1 Gene Expression in Muscle After Maximal Acute Aerobic Exercise. JEPonline 2010;13(6):35-44. Animal studies suggest plasminogen activation in skeletal muscle is necessary for muscle repair. However, plasminogen activators have been studied little in humans. T...

Background and Objectives Morinda citrifolia (Noni), an important traditional medicinal plant still used in patients with bone fractures or dislocation to promote connective tissue repair and to reduce inflammation. However, the effects of Noni on bone metabolism and whether it influences the osteogenic differentiation is yet to be clarified. In this study, we investigated the effect of Morinda...

Brain ischemia may be causally related with Alzheimer's disease. Presumably, β-secretase and amyloid-β protein precursor gene expression changes may be associated with Alzheimer's disease neuropathology. Consequently, we have examined quantitative changes in both β-secretase and amyloid-β protein precursor genes in the medial temporal lobe cortex with the use of quantitative rtPCR analysis foll...

Twelve Korean infectious bronchitis viruses (IBVs) were isolated in the field from chickens suspected of being carriers of infectious bronchitis between 2001 and 2003. The S1 glycoprotein genes of these IBV isolates were amplified by reverse transcriptase-polymerase chain reaction (RTPCR) and analyzed by restriction fragment length polymorphism (RFLP) analysis. These Korean IBV isolates were cl...

BACKGROUND Vascular Endothelial Growth Factor (VEGF) is a coordinate regulator of physiological angiogenesis during embryogenesis, skeletal growth and reproductive functions. There are several types of VEGF, including VEGF165. VEGFs stimulate endothelial cell growth, angiogenesis, and capillary permeability. Low induction temperature is a major factor for expression of the recombinant VEGF165 i...

L-arginine is the common substrate for arginase and nitric oxide synthase (NOS). Arginase converts L-arginine to urea and L-ornithine. L-Ornithine is the principal precursor for the production of polyamines and L-proline, which are required for cell proliferation and collagen synthesis. Endothelial NOS is expressed in the human endometrial glandular epithelium, but the expression and physiologi...

Background: Primary cardiac sarcoma is rare tumor with a poor prognosis. Currently, complete surgical removal is only mode of therapy proven to show some benefits. If the tumor has metastases, it will demonstrate very unfavorable outcome. Here we reported a personalized chemotherapy to treat a patient suffering from cardiac sarcoma with multiple metastases. Method and findings: We obtained a pa...