The purpose of the present study was to determine the effects of diet composition and exercise on glycerol and glucose appearance rate (Ra) and on nonglycerol gluconeogenesis (Gneo) in vivo. Male Wistar rats were fed a high-starch diet (St, 68% of energy as cornstarch, 12% corn oil) for a 2-wk baseline period and then were randomly assigned to one of four experimental groups: St (n = 7), high-f...

Exercise appears to improve glycemic control for people with type 1 diabetes (T1D). However, the mechanism responsible for this improvement is unknown. We hypothesized that exercise has a direct effect on the insulin-producing islets. Eight-week-old mice were divided into four groups: sedentary diabetic, exercised diabetic, sedentary control, and exercised control. The exercised groups particip...

19 Increased physical activity is recommended for the general population and to patients of many 20 diseases because of its health benefits but can be contraindicated if it is thought a risk for serious 21 cardiovascular events. One such condition is pulmonary artery hypertension (PAH). PAH and right 22 ventricular failure was induced in rats by a single injection of monocrotaline (MCT). MCT ra...

Synopsis. We used a novel mouse model to study the effects of selective breeding for high locomotor activity (14 generations) on relative organ sizes, hematocrit (Hct), and blood hemoglobin (Hb) concentration. We also examined effects of exercise training and gene-by-environment interactions by housing animals for 8 weeks with wheels that were either free to rotate or locked. Mice from the four...

L-DOPA alleviates the motor symptoms of Parkinson's disease, but its long-term use is associated with undesirable dyskinesia. We now tested whether exercise can attenuate this L-DOPA-induced dyskinesia (LID). We tested the effects of exercise on LID in 6-hydroxydopamine hydrochloride-hemiparkinsonian mice. Animals were treated with L-DOPA/benserazide (25/12.5 mg/kg, i.p.) without and with possi...

Studies of rodents have shown that both forced and voluntary chronic exercise cause increased hindlimb bone diameter, mass, and strength. Among species of mammals, "cursoriality" is generally associated with longer limbs as well as relative lengthening of distal limb segments, resulting in an increased metatarsal/femur (MT/F) ratio. Indeed, we show that phylogenetic analyses of previously publi...

Exercise training induces many adaptations in skeletal muscle, representative examples of which include an increase in the IIa myofibre and an increase in the capillary-to-fibre ratio (C:F ratio). Moreover, these phenomena are thought to be dependent on running distance. Ibuprofen is one non-steroidal anti-inflammatory drug that is often used as an analgesic, but its effect on skeletal muscle a...

Activity-based anorexia (ABA) is a widely used animal model for identifying the biological basis of excessive exercise and starvation, 2 hallmarks of anorexia nervosa (AN). Anxiety is correlated with exercise in AN. Yet the anxiety level of animals in ABA has not been reported. We asked: Does food restriction as part of ABA induction change the anxiety level of animals? If so, is the degree of ...

Clah, Leon. M.S., Purdue University, May 2015. Type Physical Activity in Pregnant Dams Reduces Mammary Tumor Formation in Rat Offspring. Major Professor: Ignacio Camarillo. Breast cancer is the most frequently diagnosed cancer and a leading cause of cancer death among women. Lifestyle factors such as physical activity and diet play a role in attenuating the incidence of breast cancer. Current r...

A 01 VOLUNTARY WHEEL RUNNING CAN IMPROVE INCREASED UROGENITAL SENSITIVITY AND FUNCTION RESULTING FROM NEONATAL MATERNAL SEPARATION IN MALE MICE Isabella M. Fuentes, Angela N. Pierce, Olivia C. Eller-Smith, Julie A. Christianson Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas, USA Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) shares m...