The durations of the cell cycle intervals of the murine Sarcoma 180 tumor were determined by computer analysis of the fraction-labeled mitosis curve following tritiated thymidine administration. This tumor has a usual total cell cycle duration of 19.6 hr, a DNA synthetic time of 8.3 hr, and a growth fraction of 1. Approximately 38% of cells are in S phase at one time. Hydroxyurea (HU) infusions...

PURPOSE The goal of this study is to optimize the activity of trabectedin for Ewing sarcoma by developing a molecularly targeted combination therapy. EXPERIMENTAL DESIGN We have recently shown that trabectedin interferes with the activity of EWS-FLI1 in Ewing sarcoma cells. In this report, we build on this work to develop a trabectedin-based combination therapy with improved EWS-FLI1 suppress...

primary kaposi sarcoma of penis is very rare. we will introduce a 47 years old male patient referred to our clinic from dermatology service, in this report. the patient suffered from itchy penile papules around coronal region. the lab tests had revealed a negative serology of hiv but tissue pcr was positive for human herpesvirus-8 (hhv8).  histological findings were compatible with kaposi sarco...

Abstract Follicular dendritic cell (FDC) sarcoma, a rare tumor of FDCs, poses diagnostic challenge due to its myriad morphologic and architectural patterns. We present unique case extra-nodal FDC sarcoma occurring in 28-year-old gentleman who presented with multiple pelvic, peritoneal retroperitoneal soft tissue, axial skeletal lesions. The was composed islands trabeculae epithelioid cells inte...

testicular chloroma is an unusual form of extramedullary acute myeloid leukemia. we present a rare case that after chemotherapy relapsed with the appearance of metachronous testicular chloroma and we suggest prophylactic radiotherapy.

treatment with intensification of chemotherapy using alkylating agents and topoisomerase ii inhibitors and radiotherapy has improved the outcome of patients with solid tumors such as ewing’s sarcoma. however, there are several reports of secondary malignancy following treatment of these tumors. in this article, we describe a 12 years old girl with all who had ewing’s sarcoma when she was 8 year...

multiple primary tumors in a single patient are relatively rare when four or more distinct lesions are considered. herein, we report a case of woman with four different primary tumors: meningioma, renal angiomyolipoma, spinal ependymoma and high-grade soft tissue sarcoma. there was no family history and hereditary syndrome. the genetic analysis was completely normal. to best of our knowledge, t...

WO previous workers have estimated the number of pairs of genes controlling Tthe response of the chicken to Rous sarcoma virus. PRINCE (1958) proposed (a) that a single pair of autosomal alleles controlled susceptibility and resistance of chorioallantoic membranes to Rous sarcoma virus and (b) that susceptibility (allele S) was dominant to resistance (s) . This proposal was based on the proport...

Chick embryos, chick embryo fibroblasts, and Rous sarcoma virus-transformed chick embryo fibroblasts contain a factor that preferentially blocks the accumulation of DNA-directed RNA polymerase II transcripts. The factor was detected by inhibition of transcription in a cell-free assay system utilizing partially purified RNA polymerase II from calf thymus, soluble factors from HeLa cells, and a p...

Synovial sarcoma develops as a primary neoplasm of soft tissues, particularly of the extremities, but it has been also reported in a large variety of sites. This tumor is not derived from “synovium”, but from immature mesenchymal elements. Synovial sarcoma accounts for approximately 8-14% of soft tissue sarcomas (1, 2). Although metastases to the lung and/or pleural cavity are common events in ...