نتایج جستجو برای: s tnf

تعداد نتایج: 761629  

2016
B. Li S. H. Chen H. J. Lu Y. Tan

Background: To inves gate the expression of TNF-α, IL-6, IL-10 in the plasma of pa ents with lung cancer who received radia on therapy (RT), and to analyze the correla on between these cytokines and radia on pneumoni s (RP). Materials and Methods: Pa ents with lung cancer who received 3DCRT in our hospital were prospec vely evaluated. Circula ng cytokine levels were measured with ELISA before R...

2015
Yong Qiao Hao Feng Tao Zhao Heng Yan He Zhang Xin Zhao

BACKGROUND Elderly patients are reportedly at higher risk of postoperative cognitive dysfunction (POCD) after inhalational anesthesia with sevoflurane. We hypothesized that the incidence of POCD would be higher in elderly patients undergoing major surgery under inhalational rather than intravenous anesthesia. We also measured plasma S-100β protein concentration as a biomarker of central nervous...

2016
Sangeeta Singh Gyanendra Kumar Sonkar Shinjini Singh Usha Singh

Psoriasis is a T cell mediated inflammatory skin disease. Complex network of cytokine induces and maintain the psoriatic lesion. Study was performed to evaluate the correlation between the level of TNFα and IL-6, in the psoriasis patients with HLA-Cw6. Cytokine levels were assayed by sandwich ELISA and HLA-Cw6 typing was done by microcytoxicity method. Serum TNF-α and IL-6 were significantly (p...

Journal: :iranian journal of basic medical sciences 0
haifeng teng weihai municipal hospital, china meng chen yantai yuhuangding hospital of laishan branch, china ansheng chu yantai city hospital for infectious diseases, china haili jiang shuguang hospital, shanghai university of traditional chinese medicine, china jichun han shandong provincial qianfoshan hospital, china long sun yishui central hospital, china

objective(s): the objective of this study was to investigate the hepatoprotective effect of licochalcone b (lcb) in a mice model of carbon tetrachloride (ccl4)-induced liver toxicity. materials and methods: hepatotoxicity was induced in mice by a single subcutaneous injection (sc) of ccl4. the lcb was administered orally once a day for seven days (po) as pretreatment at three doses of 1, 5, and...

Journal: :iranian journal of basic medical sciences 0
hadi yousefi tuberculosis & lung research center, tabriz university of medical sciences, tabriz, iran naser ahmadiasl tuberculosis & lung research center, tabriz university of medical sciences, tabriz, iran alireza alihemmati department of anatomy and histology, faculty of medicine, tabriz university of medical sciences, tabriz, iran parisa habibi tuberculosis & lung research center, tabriz university of medical sciences, tabriz, iran

objective(s):acute kidney injury (aki), a syndrome characterized by decreased glomerular filtration, occurs in every 1 of 5 hospitalized patients.  renal ischemia-reperfusion, one of the main causes of aki, is of particular importance in the setting of kidney transplantation. materials and methods: sixty male rats were divided into four groups including control, nephrectomy, sham surgery and re...

Journal: :The Journal of clinical investigation 1993
T Yokoyama L Vaca R D Rossen W Durante P Hazarika D L Mann

To define the mechanism(s) responsible for the negative inotropic effects of tumor necrosis factor-alpha (TNF alpha) in the adult heart, we examined the functional effects of TNF alpha in the intact left ventricle and the isolated adult cardiac myocyte. Studies in both the ventricle and the isolated adult cardiac myocyte showed that TNF alpha exerted a concentration- and time-dependent negative...

Journal: :The American journal of tropical medicine and hygiene 1996
T Nagao H Uemura T Yanagi K Oishi T Nagatake H Kanbara

In Plasmodium-infected mammals, phagocytosis and production of tumor necrosis factor (TNF) by monocytes and macrophages are prominent features. The present work aimed at clarifying the relationship between the maturation of human monocytes to macrophages and their TNF productivity and phagocytic ability in the presence of Plasmodium falciparum-infected erythrocytes. Fresh monocytes produced a s...

Journal: :Cardiovascular research 2000
W Song X Lu Q Feng

OBJECTIVE It has been demonstrated that tumor necrosis factor-alpha (TNF alpha) induces apoptosis in cardiac myocytes. However, its mechanism of action is still not well understood. In the present study, we hypothesized that TNF alpha induces myocardial apoptosis by induction of inducible nitric oxide synthase (iNOS). METHODS Neonatal cardiac myocytes were isolated from iNOS (-/-) mutant and ...

Journal: :Molecular and cellular biology 1998
P Schwenger D Alpert E Y Skolnik J Vilcek

Many actions of the proinflammatory cytokines tumor necrosis factor (TNF) and interleukin-1 (IL-1) on gene expression are mediated by the transcription factor NF-kappaB. Activation of NF-kappaB by TNF and IL-1 is initiated by the phosphorylation of the inhibitory subunit, IkappaB, which targets IkappaB for degradation and leads to the release of active NF-kappaB. The nonsteroidal anti-inflammat...

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