The chromatin structure of heat shock protein (HSP)-encoding genes undergoes dramatic alterations upon transcriptional induction, including, in extreme cases, domain-wide nucleosome disassembly. Here, we use a combination of gene knock-out, in situ mutagenesis, chromatin immunoprecipitation, and expression assays to investigate the role of histone modification complexes in regulating heat shock...

From yeast to human, the Spt-Ada-GCN5-acetyltransferase (SAGA) gigantic complex modifies chromatin during RNA polymerase II initiation and elongation steps facilitate transcription. Its enzymatic activity involves a histone acetyltransferase module (HATm) that acetylates multiple lysine residues on N-terminal tails of histones H2B H3 deubiquitination (DUBm) triggers co-transcriptional H2B. With...

THE THEME of this project are the future information agents , also known as ubiquitous or pervasive agents. Ubiquitous information agents have computation abilities and the power to act on their physical environments. Examples include complex systems such as robot companions, self-driving cars (e.g., Stanford or Google), simpler agents as in smart elderly homes and AAL, mobile travel devices, s...

ABSTRACT We study the relative fractions of quenched and star-forming satellite galaxies in Satellites Around Galactic Analogs (SAGA) survey Exploration Local VolumE (ELVES) program, two nearby complementary samples Milky Way-like that take different approaches to identify faint galaxy populations. cross-check validate sample cuts selection criteria, as well explore effects star-formation defin...