The gene encoding methylthioadenosine phosphorylase (MTAP), the initial enzyme in the methionine salvage pathway, is deleted in a variety of human tumors and acts as a tumor suppressor gene in cell culture (Christopher, S. A., Diegelman, P., Porter, C. W., and Kruger, W. D. (2002) Cancer Res. 62, 6639-6644). Overexpression of the polyamine biosynthetic enzyme ornithine decarboxylase (ODC) is fr...

UNLABELLED The usual management of upper aero digestive tract squamous cell carcinoma is surgery associated or not to post surgical radiotherapy. Loco-regional relapses constitute the main failure of the initial treatment and early diagnosis justifies the indication of salvage surgery. AIM Descriptive analysis of demographic data and staging for salvage surgery of oropharynx tumors. MATERIA...

BACKGROUND Isolated limb perfusion (ILP) may provide a limb salvage option for locally advanced soft tissue sarcoma (STS) not amenable to local resection. METHODS A systematic review was performed for studies reporting outcome of ILP for locally advanced STS performed after 1980 in patients aged ≥ 12 years old. The main endpoints were tumour response and limb salvage rates. Complication and r...

INTRODUCTION Despite aggressive multidisciplinary interventions, patients with high-grade astrocytomas experience tumour progression or recurrence. Treatment for this group of patients remains a formidable challenge. We describe our experience of salvage chemotherapy for these patients. MATERIALS AND METHODS A retrospective review of relevant clinical and radiographic information of patients ...

OBJECTIVES This study evaluates the association between microvascular obstruction and myocardial salvage, determined by cardiac magnetic resonance performed both in the acute stage of myocardial infarction and after 4 months. METHODS In patients with acute ST-elevation myocardial infarction treated by primary percutaneous coronary intervention, myocardial salvage, infarct size, left ventricul...

OBJECTIVES The purpose of this study was to determine the extent to which the Mangled Extremity Severity Score (MESS) predicted outcomes for soldiers sustaining combat-related Gustilo-Anderson type III open tibia fractures. DESIGN Retrospective cohort study. SETTING Tertiary trauma center. PATIENTS Service Members with combat-related type III open tibia fractures occurring between 2003 an...

General commentary to the " Management of biochemical recurrence after primary localized therapy for prostate cancer " TO THE EDITOR: In a recently published review on management of patients with biochemical failure (BF) following primary definitive therapy for localized prostate cancer (PCa), Darwish and Raj (2012) stated that following radical prostatectomy (RP) patients who are at high risk ...

With growing experience, the indications for salvage extracorporeal membrane oxygenation continue to expand. We describe a successful application of extracorporeal support in a polytrauma patient presenting with profound hypothermia, respiratory failure, and whom was later found to have an intracranial hemorrhage. We advocate the role of salvage therapy even in patients with complex pathophysio...

Technological advances have allowed reconstructive foot and ankle surgeons greater opportunity to provide significant limb salvage options to those patients who present with significant lower extremity deformity due to diabetic Charcot neuroarthropathy. Paradigms that promote the utilization of these advanced modalities have demonstrated significant improved limb salvage outcomes in this challe...

THE JOURNAL OF BONE AND JOINT SURGERY G. Bacci, MD S. Ferrari, MD A. Longhi, MD C. Forni, RN M. Versari, MA Department of Chemotherapy S. Lari, MD Department of Anaesthesia M. Mercuri, MD D. Donati, MD 5th Ward of Orthopaedic Surgery F. Bertoni, MD Service of Anatomy and Pathology E. Pignotti, MA Service of Statistics of the Department of Musculoskeletal Oncology Rizzoli Orthopaedic Institute, ...