We used primary cultures of trout hepatocytes and a physiological dose of cortisol (100 ng/ml), mimicking stressed levels in salmonid fish, to address the impact of glucocorticoid stimulation on glucocorticoid receptor (GR) mRNA abundance and protein content. Cortisol significantly elevated GR mRNA content over a 24-h period; this increase was abolished by actinomycin D, suggesting transcriptio...

Polymorphonuclear leukocytes (PMNs) can be divided into Gr-1(high) and Gr-1(low) subpopulations, but the differences in the functions of these cells in the host are unknown. This study investigated the roles of these two cell populations in the clearance of an intracellular pathogen (Haemophilus influenzae) causing murine peritonitis and pneumonia. Microarray analysis and quantitative real-time...

compared to quartz sand, the shear behavior of carbonate sand differs in  appearance, origin, and kind. carbonate sand is found mainly in the northern coast of the persian gulf and the oman sea. in this research, a comparison is made between the shear behavior of carbonate sand retrieved from the eastern region of the chabahar port, located north of the oman sea, and quartz sand obtained from f...

We compare the deformation patterns produced by sand and a sand mica mixture (14:1 ratio of sand to mica by weight) while simulating basin fill in extension and inversion models to analyze the potential of the sand mica mixture for applications that require a strong elasto-frictional plastic analogue material in physical models. Sand and the sand mica mixture have nearly equal angles of interna...

The Y chromosome carries several spermatogenesis genes distributed in three regions: AZFa, AZFb and AZFc. Microdeletions in these regions have been seen in 10% of sterile males with azoospermia or oligozoospermia, the most frequent of them being characterized by a complete deletion of AZFc region. A partial AZFc deletion named gr/gr has been singled out as a risk factor for spermatogenic failur...

Glucocorticoid hormones are critical to respond and adapt to stress. Genetic variations in the glucocorticoid receptor (GR) gene alter hypothalamic-pituitary-adrenal (HPA) axis activity and associate with hypertension and susceptibility to metabolic disease. Here we test the hypothesis that reduced GR density alters blood pressure and glucose and lipid homeostasis and limits adaption to obesoge...

The glucocorticoid receptor (GR) is a ligand-regulated transcription factor that controls the expression of extensive gene networks, driving both up- and down-regulation. GR utilizes multiple DNA-binding-dependent and -independent mechanisms to achieve context-specific transcriptional outcomes. The DNA-binding-independent mechanism involves tethering of GR to the pro-inflammatory transcription ...

There are several types of firing tests of cannonballs. In ground firing tests, cannonballs without gunpowder charged are fired against sand heap. When a cannonball collides into sand, the cannonball’s penetration depth, stress and sand temperature depend on the sand properties. Sand tends to become harder than before after plenty of cannonball firing. This is because kinetic energy of a cannon...

Abstract This study examines the use of sillimanite as a fine aggregate in production temperature-resistant reactive powder concrete. The impact high temperatures on mechanical strength concrete with High Alumina cement is investigated. effectiveness utilizing glass and properties RPC at investigated this research. samples were heated muffle furnace to desired then tested for their residual com...

Lead (Pb) is a non-essential element; however, plants uptake it from soils rich in Pb. Soybean [Glycine max (L.) Merr.] an important legume crop, and Pb toxicity exerts negative impacts on its growth yield. This study investigated the role of foliar-applied loquat (Eriobotrya japonica Lindl.) leaf extract improving morphological, physiological, biochemical traits soybean under toxicity. were ex...