Abstract Background SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis, and osteitis) is a rare, heterogeneous, self-limited disease of unknown etiology. It involves progressive bone joint damage, skin lesions may occur at different times in the course disease. Skin are characterized by neutrophil dermatosis. Its management empirical mainly symptomatic, nonsteroidal anti-inflammatory dru...

Abstract Background The acronym SAPHO stands for synovitis, acne, pustulosis, hyperostosis, and osteitis. It is a rare heterogenous disease with unknown etiology chronic relapsing remitting course 1 . Its skin osteoarticular manifestations including palmoplantar pustulosis (PPP) synovitis may be transient which further complicate the diagnosis. So, awareness about all features of syndrome throu...