نتایج جستجو برای: sar structureactivity relationship
تعداد نتایج: 569880 فیلتر نتایج به سال:
A novel chemical class of potent chemoattractant receptor-homologous expressed on Th2 lymphocytes (CRTH2 or DP2) antagonists is reported. An initial and moderately potent spiro-indolinone compound ( 5) was found during a high-throughput screening campaign. Structure-activity relationship (SAR) investigation around the carboxylic acid group revealed that changes in this part of the molecule coul...
Many studies about the vegetation layer by means of SAR tomography are model based or make use of some sort of superresolution algorithms. By one side such approaches are often necessary because of the limited resolution characterizing the datasets. On the other side results can be easily a ected by poor accuracy whenever the model does not t. In this paper a totally model free approach is prop...
We introduce the Statistical Asynchronous Regression (SAR) method: a technique for determining a relationship between two time varying quantities without simultaneous knowledge of both quantities. We require that there is a time invariant, monotonic function Y = u(X) relating the two quantities, Y and X. In order to determine u(X), we only need to know the statistical distributions of X and Y. ...
Objective: Soil salinity is one of the major worldwide environmental constraints affecting agricultural production in arid and semiarid regions. Lack of proper management of water and soil resources lead to increase soil salinity and reduce soil fertility. On the other hand, it seems simple and cheap method of measuring soil salinity is necessary. The aim of this study was to determine the rela...
The world is experiencing population ageing, which will extend to the future across world. ageing sure impact a country’s welfare policy and economy. Macau special administrative region (SAR) of China with long-life expectancy decreasing reproduction rate, making particularly obvious. This study adopts mixed methods approach analyze relationship between population, pension recipients, payments ...
Bistatic SAR data are more complicated to process than monostatic data because of the versatile sensor geometry and the non-stationary properties of the received data. Recent approaches to the processing of bistatic SAR data have revolved around finding an accurate representation of the two-dimensional spectrum for a point target. In this paper, we review past methods of obtaining the spectrum,...
Apelin is the endogenous ligand of the APJ receptor, a member of the G-protein-coupled receptor family. The apelin-APJ complex has been detected in many tissues and is emerging as a promising target for several pathophysiological conditions. There is currently little information on the structure-activity relationship (SAR) of the apelin hormone. In an effort to better delineate SAR, we synthesi...
Based on the natural isoprenyl phenyl ether from a mangrove-derived fungus, 32 analogues were synthesized and evaluated for inhibitory activity against influenza H1N1 neuraminidase. Compound 15 (3-(allyloxy)-4-hydroxybenzaldehyde) exhibited the most potent inhibitory activity, with IC(50) values of 26.96 μM for A/GuangdongSB/01/2009 (H1N1), 27.73 μM for A/Guangdong/03/2009 (H1N1), and 25.13 μM ...
Matched molecular pairs (MMPs) are widely used in medicinal chemistry to study changes in compound properties including biological activity, which are associated with well-defined structural modifications. Herein we describe up-to-date versions of three MMP-based data sets that have originated from in-house research projects. These data sets include activity cliffs, structure-activity relations...
The relationship between structure and inhibition activity on carbonic anhydrase I of a set of forty substituted 1,3,4-thiadiazoleand 1,3,4-thiadiazoline-disulfonamides has been investigated by using the Molecular Descriptors Family method. The molecular descriptors family has been generated starting with the information obtained from the compounds structure and the descriptors were calculated....
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