Uterine sarcomas are rare female genital tract malignancies. Mullerian adenosarcoma is a biphasic malignant mesenchymal tumor comprising of benign glandular and (usually low grade) stromal component, both which integral neoplastic constituents the tumor.[1] This represents less than 8% uterine sarcomas. About 200 cases have been reported in literature so far [2] 22 case were from India. Adenosa...

Bone sarcomas are rare tumour entities that arise from the mesenchyme most of which highly heterogeneous at cellular, genetic and epigenetic levels. The three main types osteosarcoma, Ewing sarcoma, chondrosarcoma. These oncological characterised by high morbidity mortality an absence significant therapeutic improvement in last four decades. In field oncology, vitro cultures cancer cells have b...

Sarcomas are thought to originate from mes-enchymal tissue, and account for 1% of adult solid malignancies and over 20% of pediatric solid malignances. Nearly 11,000 people in the USA and 200,000 people in the world will be diagnosed with sarcomas each year [101]. When they metastasize, sarcomas typically have a very poor outcome. Unlike other types of tumors, the molecular basis and accompanyi...

Objective: This is a narrative review on the state of art multidisciplinary treatment metastatic sarcomas. We aim to report and analyze indications chemo-radio surgical currently suggested by results principal studies reported in literature.

Despite extensive research efforts over the past two decades to identify effective agents for the treatment of soft tissue sarcomas, few agents are available, and with modest utility. There is a high unmet medical need to develop novel therapies for the treatment of patients with soft tissue sarcomas. Clinical trials for soft tissue sarcomas should be optimally designed, and it is crucial that ...

Modulation of apoptosis may influence sarcoma pathogenesis and/or aggressiveness. The Fas death pathway, mediated by FasL or TGFbeta, is one of two apoptotic pathways. Recent studies report that EGF can modulate TGFbeta and/or FasL expression/activity; thus, EGF has the potential to influence activation of the Fas pathway. EGF is not always detectable in mesenchymal tumors; therefore, we hypoth...

Sarcomas are cancers arising from the mesenchymal layer that affect children, adolescents, young adults, and adults. Although most sarcomas are localized, many display a remarkable predilection for metastasis to the lungs, liver, bones, subcutaneous tissue, and lymph nodes. Additionally, many sarcoma patients presenting initially with localized disease may relapse at metastatic sites. While loc...

p53 Transgenic mice were crossed with C57BL/6J mice to investigate whether a germ-line mutation in the p53 gene predisposes for tumorigenesis in mice. (C57BL/6J x UL53-3) F(1) mice were treated with 1,2-dimethylhydrazine (DMH), a colon carcinogen. The presence of a mutant p53 led to an increased incidence or multiplicity of uterine sarcomas, colon carcinomas, lung adenomas, and hepatomas in DMH...

Soft tissue sarcomas are aggressive tumors representing <1% of all adult neoplasms. Aim of our study was to evaluate promyelocytic leukemia gene expression value as prognostic factor and as a factor predicting response to alkylating agents/antracycline-based first line therapy. One hundred eleven patients affected by locally advanced and metastatic soft tissue sarcoma were selected. PML express...

Sarcomas are rare malignant mesenchymal tumors for which there are limited treatment options. One potential molecular target for sarcoma treatment is the Src tyrosine kinase. Dasatinib (BMS-354825), a small-molecule inhibitor of Src kinase activity, is a promising cancer therapeutic agent with p.o. bioavailability. Dasatinib exhibits antitumor effects in cultured human cell lines derived from e...