B evacizumab (Avastin) is a full-length recombinant humanized monoclonal antibody directed against vascular endothelial growth factor (VEGF). It has been approved by the US Food and Drug Administration for the treatment of metastatic colorectal cancer. Intravitreous (IV) injection of bevacizumab, 1.25 mg/0.05 mL, has been studied in patients with age-related macular degeneration, macular edema ...

3. Side, L, Taylor B, Cayouette M , et al. Homozygous inactivation of the NF1 gene in bone marrow cells from children with neurofibromatosis type 1 and malignant myeloid disorders. N Engl J Med 1997; 336: 1713-20. 4. Matsui I, Tanimura M, Kobayashi N, Sawada T, Nagahara N, Akatsuka J. Neurofibromatosis type 1 and childhood cancer. Cancer 1993; 72:2746-54. 5. Friedman JM, Birch PH. Type 1 neurof...

Our research over the past two years has focussed on malleable caches and processors for data-intensive computing. We have worked closely with a researcher at NTT on improving the memory and caching needs of speech applications. Hiroshi Sawada, our NTT colleague, visited us last year for about six months, and reported on collaborative work at the NTT Japan meeting in January. Hiroshi is now exa...

An assumption based on the Jarman-Bell principle suggests a positive relationship between body size and the digestive efficiency in animals, where smaller animals are less effective at digesting fibrous food due to shorter digesta passage. To examine the effect of body size within a species and explore a potential physiological background of ontogenetic diet shifts, we measured food intake, dig...

4 Kiyofumi Mochizuki, MD, PhD, Akira Sawada, MD, PhD, Shinsuke Suemori, MD, PhD, 5 Hideaki Kawakami, MD, PhD, Yoshiaki Niwa, MD, PhD, Yuji Kondo, MD, PhD, Kiyofumi 6 Ohkusu, PhD, Noriaki Yamada, MD, Shinji Ogura, MD, PhD, Takashi Yaguchi, PhD, Kazuko 7 Nishimura, MD, PhD, Satoshi Kishino, PhD 8 9 Department of Ophthalmology, Gifu University Graduate School of Medicine, Gifu 10 Department of Oph...

In order to settle the fundamental question whether the nuclear forces involve the long range components, the S-wave amplitude of the proton-proton scattering is analysed in search for the extra singularity at ν = 0, which corresponds to the long range force. To facilitate the search, a function, which is free from the singularities in the neighborhood of ν = 0 when all the interactions are sho...

1. Naidich TP, Daniels DL, Pech P, Haughton VM , Williams A, Pojunas K. Anterior commissure: anatomic-MR correlation and use as a landmark in three orthogonal planes. Radiology 1986;158 :421-429 2. Strich SJ. Diffuse degeneration of the cerebral white matter in severe dementia following head injury. J Neural Neurasurg Psychiatry 1956;19 :163-185 3. Nevin NC. Neuropathological changes in the whi...

which has a matrix Lax pair [, ] and is shown to be related to a negative flow in the Sawada-Kotera hierarchy. Several conservation quantities and a bi-Hamiltonian structure were found in []. Himonas and Holliman [] applied the Galerkin-type approximation method to prove the well-posedness of strong solutions for Eq. () in the Sobolev space Hs(R) with s >  on both the line and the circle....

Takens, Ruelle, Eckmann, Sano and Sawada launched an investigation of images of attractors of dynamical systems. Let A be a compact invariant set for a map f on Rn and let φ : Rn → Rm where n > m be a “typical” smooth map. When can we say that A and φ(A) are similar, based only on knowledge of the images in Rm of trajectories in A? For example, under what conditions on φ(A) (and the induced dyn...