Staphylocoagulase (SC) is a potent nonproteolytic prothrombin (ProT) activator and the prototype of a newly established zymogen activator and adhesion protein family. The staphylocoagulase fragment containing residues 1-325 (SC-(1-325)) represents a new type of nonproteolytic activator with a unique fold consisting of two three-helix bundle domains. The N-terminal, domain 1 of SC (D1, residues ...

Negative Bloodstream Infections Matthew Brigmon, MD; Sarah Cain, BS; P. Brandon Bookstaver, PharmD, BCPS, (AQ-ID), AAHIVE; Joseph Kohn, PharmD, BCPS; Helmut Albrecht, MD; Majdi Al-Hasan, MD; Medicine, Palmetto Health/University of South Carolina School of Medicine, Columbia, SC; University of South Carolina School of Medicine, Columbia, SC; University of South Carolina College of Pharmacy, Colu...

PURPOSE To evaluate the in vivo changes in the Schlemm's canal (SC) in patients with primary angle-closure glaucoma (PACG) after trabeculectomy using spectral-domain optical coherence tomography (SD-OCT). METHODS Forty eyes of 40 patients with PACG who underwent trabeculectomy were included. All participants underwent SD-OCT. The diameter and area of SC were examined and measured before and w...

UNLABELLED In recent years, (47)Sc has attracted attention because of its favorable decay characteristics (half-life, 3.35 d; average energy, 162 keV; Eγ, 159 keV) for therapeutic application and for SPECT imaging. The aim of the present study was to investigate the suitability of (47)Sc for radionuclide therapy in a preclinical setting. For this purpose a novel DOTA-folate conjugate (cm10) wit...

Introduction: The head scatter factor (Sc) is important to measurements radiation beam and beam modeling of treatment planning systems used for advanced radiation therapy techniques. This study aimed to investigate the design of a mini-phantom to measurement variations in collimator Sc in the presence of shielding blocks for shaping the beam using different field sizes. <str...

Chronic wasting disease (CWD), a transmissible prion disease that affects elk and deer, poses new challenges to animal and human health. Although the transmission of CWD to humans has not been proven, it remains a possibility. If this were to occur, it is important to know whether the "acquired" human prion disease would show a phenotype including the scrapie prion protein (PrP(Sc)) features th...

The caudal superior colliculus (SC) contains movement neurons that fire during saccades and the rostral SC contains fixation neurons that fire during visual fixation, suggesting potentially different functions for these 2 regions. To study whether these areas might have different projections, we characterized synaptic inputs from the rostral and caudal SC to inhibitory burst neurons (IBNs) in a...

Previously, we demonstrated that genistein stimulated Cl(-) secretion in the mouse jejunum (Baker MJ and Hamilton KL, Am J Physiol Cell Physiol 287: C1636-C1645, 2004); however, the mode of action of genistein still remains unclear. Here, we examined the activation of Cl(-) secretion by the modulation of phosphodiesterases (PDEs) by genistein (75 microM) in the mouse jejunum with the Ussing sho...

As a collection of entities with common goals, supply chain (SC) has a unique system structure. Taxonomy is the mechanism for collecting, structuring, and classifying information about a system. This paper proposes taxonomy for SC system. It is built around a dynamic constraint network that describes SC relationships in time among its product, process, and resource components. SC characteristic...

1. University of South Carolina, School of Medicine Dept. of Cell Biology and Anatomy. Columbia, SC USA. 2. University of South Carolina, Biomedical Engineering Program. Columbia, SC USA. 3. Medical University of South Carolina, Dept. of Surgery. Charleston, SC USA 4. University of South Carolina, School of Medicine, Dept. of Surgery. Columbia, SC USA. 5. University of South Carolina, School of...