To further investigate the importance of insulin signaling in the growth, development, sexual maturation and egg production of adult schistosomes, we have focused attention on the insulin receptors (SjIRs) of Schistosoma japonicum, which we have previously cloned and partially characterised. We now show, by Biolayer Interferometry, that human insulin can bind the L1 subdomain (insulin binding d...

Infection with Schistosoma japonicum causes high levels of pathology that is predominantly determined by the cellular and humoral response of the host. However, the specific antibody response that arises during the development of disease is largely undescribed in Asian schistosomiasis-endemic populations. A schistosome protein microarray was used to compare the antibody profiles of subjects wit...

pathologically important Platyhelminthes include the digenetic trematodes Opisthorchis, Clonorchis, Paragonimus, Fasci%psis and Fascio/a and the cestodes (tapeworms). Ali the schistosomes that mature in man belong to the genus Schistosoma of the family Schistosomatidae, which contains Il other genera, some of which cause cercarial dermatitis (Rollinson & Southgate, 1987). The genus Schistosoma ...

BACKGROUND Schistosomiasis japonica is a zoonotic parasitic disease and oral vaccine delivery system would be benefit for prevention of this disease. Although attenuated salmonella has been used as an antigen expression vector for oral vaccine development, the membrane-bound vacuoles in which bacteria reside hinders the presentation of expressed heterologous antigens to the major histocompatibi...

BACKGROUND Chemotherapy based on repeated doses of praziquantel is still the most effective control strategy against Schistosomiasis, however artemisinin derivatives emerged as a family of compounds with schistomicide activity. The aim of the present work is to compare the efficacy of artemisinin-based therapies in the treatment and prophylaxis of human schistosomiasis. The design of this work ...

Schistosomiasis, a disease affecting over 200,000,000 human beings, Is caused by Infection with one of sev­ eral species of the Schistosoma trematodes. The In­ fectious form for mammals Is the cercaria developed by passage through snails. The major cause of death In those Infected results from distortion_ of the hepatic circulation caused by a unique kind of fibrosis In the liver. The fibrosis ...

BACKGROUND Schistosomiasis in the People's Republic of China (PRC) can be traced back to antiquity. In the past 60 years, the Chinese government has made great efforts to control this persistent disease with elimination slated by 2020 through the implementation of a comprehensive control strategy. This strategy aims to reduce the role of bovines and humans as sources of infection as a pre-requi...

The global burden of schistosomiasis is significant, with fibrosis a major associated morbidity and the primary cause of mortality. We have previously shown that schistosomiasis during pregnancy upregulates proinflammatory cytokines in the cord blood. In this study, we extend these findings to include a large panel of fibrosis-associated markers. We developed a multiplex bead-based assay to mea...

Imaging diagnosis based on ultrasonic findings of the liver with Schistosomiasis Japonica has been recently reported (Nakayama et al. 1981 Uto et al. 1984). In the present study, attempts were made to classify the ultrasonic patterns of the liver infected with Schistosoma Japonicum. The calcification and fibrosis of the liver were evaluated by comparative investigation with an ultrasonogram and...

Whereas the epidemiologic study of parasitic helminth in Thailand have been reported by several authors, that of Laos and Cambodia is little known at present. We have an opportunity of visiting South Laos and Cambodia along Mekong River Basin in order to make a survey on schistosomiasis in 1960. During the staying period of one and a half months in that region, our survey was focused on three s...