Abstract Background Emotional intelligence is usually a construct measured in healthy children, now it may be used for relatives of schizophrenia, and considered as trait marker schizophrenia. Offspring parents with schizophrenia are children high familial risk major mental disorder. The aim the study to assess emotional group off springs parent compare them control subjects, find possible rela...

Introduction Plasma zonulin is acknowledged to be a biomarker for intestinal permeability. Previous studies have demonstrated significant relationships regarding potential effects of in several major psychiatric conditions including attention deficit and hyperactivity disorder, autism spectrum disorder depression, however its role schizophrenia still remains unclear. Objectives We aimed identif...

Neuregulin-1 (NRG1) is associated with schizophrenia. As one of the receptors of NRG1, v-erb-a erythroblastic leukemia viral oncogene homolog 4 (ErbB4) has also been reported to be associated with schizophrenia. Since there can be shared genetic variants among bipolar affective disorder, major depressive disorder and schizophrenia, we tested the association between ErbB4 and these three major p...

Two single nucleotide polymorphisms of PDLIM5, rs7690296 and rs11097431, were genotyped using Mass-Array SNP genotyping by Sequenom technology in 244 bipolar disorder patients, 471 schizophrenia patients, and 601 control individuals who were Malay, Chinese, and Indian ethnic groups in the Malaysian population. A significant association was observed in allele frequency between the rs7690296 poly...

This paper reviews the concept and recent studies on childhood and adolescent psychoses with special reference to schizophrenia. After a short historical introduction, the definition, classification, and epidemiology of child- and adolescent-onset psychoses are described, pointing out that some early-onset psychotic states seem to be related to schizophrenia (such as infantile catatonia) and ot...

Bipolar disorder and schizophrenia share phenotypic and genotypic features, but might differ in aspects of abnormal neurodevelopmental trajectories. We studied gyrification, a marker of early developmental pathology, in high-resolution MRI scans of 34 patients with schizophrenia, 17 euthymic bipolar I disorder patients with previous psychotic symptoms, and 34 matched healthy controls in order t...

Contrary to older views, with modern treatment some or many patients with schizophrenia may show intervals of recovery. The current 15-year prospectively designed follow-up research comparing schizophrenia patients with other types of psychotic and nonpsychotic patients studied how many schizophrenia patients ever show intervals of recovery. Two hundred seventy-four early young psychiatric pati...

Schizophrenia is a widely known mental disorder that can cause severe life struggles if not being treated properly. According to its diagnose, patients suffer from delusions, hallucinations, and other disorders. For treatment, antipsychotics are commonly used, but their efficiency cannot be promised due the lack of knowledge about this illness. In previous studies, scientists had suggested neur...

Abstract In the treatment of persons with schizophrenia goal has gradually shifted from reduction symptoms and prevention relapse to recovery. However, this is achieved for a minority schizophrenia, while most them disorder still major cause disability, poor quality life premature death, presents considerable social economic costs. Studies aimed at identifying variables significant impact on ou...

Abstract Evidence suggests that shared pathophysiological mechanisms in neuropsychiatric disorders (NPDs) may contribute to risk and resilience. We used single-gene network-level transcriptomic approaches investigate disorder-specific processes underlying posttraumatic stress disorder (PTSD), Parkinson’s disease (PD) schizophrenia a South African sample. RNA-seq was performed on blood obtained ...