BACKGROUND A triad of deformities-thoracolumbar scoliosis, pelvic obliquity, and femoral head (hip) subluxation/dislocation-occurs frequently in non-ambulatory neuromuscular patients, but their close inter-relationship is infrequently appreciated or quantified. We propose a deformity documentation approach to assess each component simultaneously. METHODS The documentation assesses each compon...

STUDY DESIGN Modified Delphi technique. OBJECTIVE To develop guidelines for the clinical management of scoliosis in Rett syndrome through evidence review and consensus expert panel opinion. SUMMARY OF BACKGROUND DATA Rett syndrome is a rare disorder and clinical expertise is thus with small case series. Scoliosis is a frequent association and the evidence base dealing with scoliosis managem...

Scoliosis is an abnormal curvature of the spine, which generally develops during childhood or adolescence. It affects 2–4 percent global population and more prevalent among girls. classified by its etiology: idiopathic, congenital, neuromuscular. Among these, former most common. Treatment options for scoliosis vary depending on severity curve. Most diagnoses tend to be mild only require monitor...

Mapping the human and mouse genomes was an enormous undertaking and is providing an incredible wealth of knowledge for basic and applied research. However, knowing the code is like taking a census of each individual in a country. Although this is an important first step, the functionality of a country cannot be known simply by knowing the names and locations of its citizens. This functionality ...

Idiopathic scoliosis is a three-dimensional deformity of the spine with lateral curvature combined with vertebral rotation. The primary lesion, however, lies in the median sagittal plane, taking the form of a lordosis. It was first described by Hippocrates, and the term “scoliosis” was first used by Galen (AD 131–201). Although the clinical manifestations of scoliosis have been well described, ...

BACKGROUND The efficacy of brace treatment for patients with adolescent idiopathic scoliosis (AIS) remains controversial. To make comparisons among studies more valid and reliable, the Scoliosis Research Society (SRS) has standardized criteria for brace studies in patients with AIS. The purpose of this study was to evaluate the efficacy of the Osaka Medical College (OMC) brace for AIS in accord...

Chronic myeloid leukemia (CML), a hematopoietic stem cell (HSC) disorder, cannot be eradicated by conventional chemotherapy or the tyrosine kinase inhibitor (TKI) imatinib mesylate (IM). This disease persistence results from a population of quiescent CML HSC that are also not effectively targeted by the second generation BCR-ABL TKIs, dasatinib (DAS) or nilotinib in vitro. To target CML stem/pr...

Uterine fibroids, or leiomyomata, are the most common tumours in women during the reproductive years and represent a significant health issue, yet little is known about their pathogenesis. We mapped a predisposition gene for multiple fibroids, cutaneous leiomyomata and renal carcinoma to chromosome 1q42.3-q43 and refined the region of the gene by mapping critical recombinants and using FISH in ...

Background A frequent question from parents of adolescents is whether there are risk factors that could make a scoliosis curve increase, specifically whether carrying a heavy backpack on one shoulder could be detrimental to an existed curve. There has been very little research published to answer whether a unilateral upper extremity load would have an effect on spine position, let alone scolios...

Adolescent idiopathic scoliosis (AIS) is a multifactorial disorder with more questions than answers. In past years, research has mainly focused on 5 areas: genetic factors, neurological mechanism dysfunction, hormone/metabolic dysfunction, skeletal growth abnormalities, and biomechanical factors. As adolescents with any known functional or structural disorder in the somatosensory pathway are mo...