Food and beverages may contain high amounts of histamine and thus may cause symptoms after ingestion. The aim of this study was to investigate the role of ingested histamine in atopic dermatitis. Patients with atopic dermatitis had to maintain a histamine-free diet for one week. Consecutively, double-blind, placebo-controlled provocations were performed with histamine-hydrochloride and placebo....

Atopic dermatitis (AD) is a chronically relapsing inflammatory skin disease, associated with basophil infiltration into skin lesions and Staphylococcus aureus (S. aureus)-induced inflammation. Pattern recognition receptors (PRRs), including microbicidal peptide human neutrophil α-defensins (HNP) and dermcidin, can exert immunomodulating activity in innate immunity and skin inflammation. We inve...

due to increasing worldwide water pollution, fish might be a source of excessive zinc, mercury, arsenic or  manganese  intake. the  aim  of  this  study  was  to  evaluate if  fish atopy/sensitization and fish consumption behavior are associated with eczema severity and blood levels of the 4 heavy metals. one-hundred and nineteen patients with eczema and 43 patients with miscellaneous non-eczem...

Oranges are suspected of inducing adverse skin reactions in patients with atopic eczema. We studied 21 adult patients with atopic eczema and a history of adverse reactions to oranges and 10 patients without. A dietary history, skin tests, serum IgE and oral provocation tests with oranges were obtained. Severity of eczema was monitored by SCORAD, and serum tryptase, eosinophil cationic protein a...

Objective: Atopic eczema (AE) is a common chronic skin disease worldwide with increasing prevalence in recent years. Literatures found its impact on health related quality of life (HRQoL) was significant for both children and adults. This study aimed to measure the HRQoL of local Chinese population with AE and make comparison with that of the Hong Kong (HK) general population. Methods: It was a...

Background Evidence for systemic treatments severe childhood eczema is limited. Systemic immunosuppressants are unlicensed use in children and associated with unwanted side effects. Objective To examine the role of anti-immunoglobulin E (IgE) [omalizumab (Xolair ® , Novartis Pharmaceuticals UK Ltd, Frimley, UK)] young people eczema. Design A double-blind, placebo-controlled, parallel-arm random...

BACKGROUND Neutrophil-lymphocyte ratio(NLR) is a novel marker for the evaluation of inflammation and has not been evaluated previously in patients with AD. OBJECTIVE To investigate the relationship between NLR and the clinical findings of AD. METHODS Sixty-six children with AD were included in the study.The control group was included 66 children who have no allergic and chronic diseases.The...

PURPOSE The clinical efficacy of subcutaneous allergen immunotherapy (SCIT) for the treatment of patients with severe atopic dermatitis (AD) using house dust mite (HDM) extract has been reported. Cyclosporin has been regarded as an effective medication for treatment of severe AD. In this study, we investigated a clinical usefulness of combined treatment with SCIT and cyclosporin in patients wit...

In patients with severe chronic atopic dermatitis (AD), both photochemotherapy [psoralen ultraviolet A (PUVA)] and narrow-band (TL-01) UV B phototherapy have been reported to be very effective. As no data exist on the relative therapeutic efficacy of these two regimens, we performed a randomized investigator-blinded half-side comparison study on 12 patients with severe chronic AD. Half-side irr...

AIM Medical records from 2010-2014 were retrospectively reviewed and analyzed in view of determining the correlations between the clinical severity of atopic dermatitis (AD) and total IgE level, eosinophilia, place of residence, family history of atopy, type of birth, and natural or artificial feeding. MATERIAL AND METHODS Following medical record review, 296 cases diagnosed with AD were incl...