Competitive interactions shape coral assemblages and govern the dynamics of ecosystems. Although competition is an ecological concept, outcomes competitive are ultimately determined by patterns gene expression. These subject to genotypic variation on both sides any interaction. Such typically treated as “noise”, but it sometimes possible identify within that reveal important hidden factors in e...

Abstract Background Secreted frizzled-related protein 5 (SFRP5) is an endogenous inhibitor of Wnt5a (wingless-type family member 5a), which has been implicated in anti-inflammatory response. In this study, we aimed to investigate whether SFRP5 could protect chondrocytes against LPS-induced inflammation and apoptosis. Methods ATDC5 cells that overexpressed with or not were challenged LPS observe...

lack of prostate specificity and intercellular localiza-tion of its gene product make this gene a poor serum biomarker. FN1 (fibronectin 1) and VEGF (vascular endo-thelial growth factor) are associated with prostate cancer and encode secreted proteins; however, these genes lack prostate-specific tissue specificity (15–18). The lack of prostate tissue specificity in the expression of these 2 gen...

The identification of membrane-associated and secreted genes that are differentially expressed is a useful step in defining new targets for the diagnosis and treatment of cancer. Extracting information on the subcellular localization of genes represented on DNA microarrays is difficult and is limited by the incomplete sequence and annotation that is available in existing databases. Here we comb...

The small leucine-rich proteoglycan lumican was identified from a human placenta cDNA library by the expression cloning method as a gene product that interacts with membrane-type matrix metalloproteinase-1 (MT1-MMP). Coexpression of MT1-MMP with lumican in HEK293T cells reduced the concentration of lumican secreted into culture medium, and this reduction was abolished by addition of the MMP inh...