We have characterized a series of genetically engineered chimeric human IgG3 and IgG4 anti-dansyl (DNS) antibodies with identical antibody-combining sites but different hinge region amino acid compositions to determine how the hinge region influences Fab fragment segmental flexibility, C1q binding, and complement activation. Our data support the correlation between "upper hinge" length and Fab ...

The present study assessed the relative contribution of each body segment to whole body fat-free mass (FFM) and impedance and explored the use of segmental bioelectrical impedance analysis to estimate segmental tissue composition. Multiple frequencies of whole body and segmental impedances were measured in 51 normal and overweight women. Segmental tissue composition was independently assessed b...

Abstract Funding Acknowledgements Type of funding sources: None. Introduction Cardiac 123I-mIBG SPECT imaging provides information on regional myocardial innervation. However, there is no consensus how to use a, 17-segment based score assess prognosis. The present study examined whether a simpler scoring approach for evaluation combined with rest 99mTc-tetrofosmin perfusion could be used the pr...

Despite advances in the curative treatment of acute myeloid leukemia (AML), recurrence will occur in the majority of cases. At diagnosis, acquisition of segmental uniparental disomy (UPD) by mitotic recombination has been reported in 15% to 20% of AML cases, associated with homozygous mutations in the region of loss of heterozygosity. This study aimed to discover if clonal evolution from hetero...

We prove that every simple transitive 2-representation of the fiat 2-category of Soergel bimodules (over the coinvariant algebra) in type B2 is equivalent to a cell 2-representation. We also describe some general properties of the 2-category of Soergel bimodules for arbitrary finite Dihedral groups.

OBJECTIVE We compared body composition estimates using an eight-electrode, segmental, multiple-frequency bioelectrical impedance analysis (segmental MF-BIA) and dual x-ray absorptiometry (DXA) in a group of healthy adults with a range of body mass indexes (BMIs). METHODS Percentage of body fat (%BF), fat-free mass, and fat mass assessed by DXA and segmental MF-BIA in 132 healthy adults were c...

BACKGROUND/AIMS Neurotensin is a gut-brain peptide with both inhibitory and excitatory actions on the colonic musculature; our objective was to understand the implications of this for motor patterns occurring in the intact colon of the rat. METHODS The effects of neurotensin with concentrations ranging from 0.1-100 nM were studied in the intact rat colon in vitro, by investigating spatio-temp...

Words can be distinguished by segmental differences or by suprasegmental differences or both. Studies from English suggest that suprasegmentals play little role in human spoken-word recognition; English stress, however, is nearly always unambiguously coded in segmental structure (vowel quality); this relationship is less close in Dutch. The present study directly compared the effects of segment...

Abstract Infantile hemangiomas (IHs) are common vascular tumors. In most cases, a benign course with favorable outcome can be anticipated. IH typically present as cutaneous lesions either localized or diffuse segmental distribution. Segmental in the face may associated brain and cardiac anomalies (PHACES syndrome), whereas airway involvement has been reported to “beard” area. Multiple visceral ...

Hybrid systems which integrate the deep neural network (DNN) and hidden Markov model (HMM) have recently achieved remarkable performance in many large vocabulary speech recognition tasks. These systems, however, remain to rely on the HMM and assume the acoustic scores for the (windowed) frames are independent given the state, suffering from the same difficulty as in the previous GMM-HMM systems...