Background and Objective: Copper is one of the main micronutrients of body which plays a key role as a cofactor in the function of metabolic enzymes. Previous studies have shown that copper sulfate () inhibits long-term potentiation (LTP) in slices of hippocampal CA1 region. Whereas LTP is involved in learning and epilepsy, it seems that copper effects on LTP could be associated with its effect...

Introduction: Epilepsy is the second most common nervous disorder after brain strok. In spite of present anticonvulsant drugs, researchers need to search for drugs with better efficacy and less side effects. Medicinal plants with various natural components so that different properties are suitable field for investigation. In this study, anticonvulsant effect of Lavandula vera DC. and Cuscuta ep...

BACKGROUND Mesial temporal lobe epilepsy (mTLE) has been suggested to follow a circadian rhythm. Previous research found an afternoon peak in mTLE seizure occurrence. We evaluated the pattern of seizure occurrence in patients with well-localized mTLE and hypothesized that peak seizure frequency would occur in the afternoon, and that this pattern would not be altered by age, gender, or seizure f...

PURPOSE Seizures frequently impact the quality of life of patients with low grade tumors. Management is often based on best clinical judgment. We examined factors that correlate with seizure outcome to optimize seizure management. METHODS Patients with supratentorial low-grade tumors evaluated at a single institution were retrospectively reviewed. Using multiple regression analysis the patien...

OBJECTIVE We identified clinical risk factors for seizure-related motor vehicle crashes in patients with epilepsy. BACKGROUND Current US laws permit epilepsy patients with controlled seizures to drive. These laws attempt to balance the important economic and social value of driving with the risk to public safety from seizure-related crashes. Various clinical factors are considered in these la...

OBJECTIVE To describe a novel neurophysiology based performance analysis of automated seizure detection algorithms for neonatal EEG to characterize features of detected and non-detected seizures and causes of false detections to identify areas for algorithmic improvement. METHODS EEGs of 20 term neonates were recorded (10 seizure, 10 non-seizure). Seizures were annotated by an expert and char...

Bang sensitive (BS) Drosophila mutants display characteristic seizure-like phenotypes resembling, in some aspects, those of human seizure disorders such as epilepsy. The BS mutant parabss1, caused by a gain-of-function mutation of the voltage-gated Na+ channel gene, is extremely seizure-sensitive with phenotypes that have proven difficult to ameliorate by anti-epileptic drug feeding or by seizu...

BACKGROUND Electroconvulsive seizure treatment is a fast-acting antidepressant therapy that evokes rapid transcriptional, neurogenic, and behavioral changes. Epigenetic mechanisms contribute to altered gene regulation, which underlies the neurogenic and behavioral effects of electroconvulsive seizure. We hypothesized that electroconvulsive seizure may modulate the expression of epigenetic machi...

In a study comparing sinusoidal wave and brief-pulse ECT in endogenous depression, seizure duration was monitored by the cuff method in 29 patients over 180 treatment sessions. Mean seizure duration across all treatments was 26.5 secs, and the mean for individual patients across their ECT course ranged from a minimum of 15.7 secs to maximum of38.5 secs. Regression analysis found no variable whi...